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Active, not recruitingNCT07360964CIRCLEUpdated Nov 4, 2026

Clear Cell Chondrosarcoma in Italy

An interventional study of Molecular studies in Chondrosarcoma, sponsored by Istituto Ortopedico Rizzoli. Active, not recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-04.

Sponsored by Istituto Ortopedico Rizzoli · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 3 months after the study started (first participant enrolled Sep 2025, registered Jan 2026).
Updated Nov 4, 2026Study completion movedGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
77
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

Clear cell chondrosarcoma of bone is considered a low-grade malignant tumor in the last WHO classification of soft tissue and bone tumors; however, it is reported that recurrences and metastasis can occur. Considering the uncertain prognosis of this rare tumor, with some cases that historically seems to pursue a bad prognosis, we decided to collect all the Italian cases of clear cell condrosarcoma, in order to better understand its natural history and prognosis.

02

Conditions studied

  • Chondrosarcoma

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Keywords

  • clear cell chondrosarcoma
  • prognosis
03

In context

Chondrosarcoma

99 studies on the registry are indexed under Chondrosarcoma; 20 are open to participants now.

This study's enrollment of 77 is above the median of 52 across 72 interventional studies indexed under Chondrosarcoma.

Browse Chondrosarcoma studies →

Lead sponsor

Istituto Ortopedico Rizzoli is the lead sponsor of 304 studies on the registry; 103 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Male and female patients with diagnosis of clear cell chondrosarcoma and chondrosarcoma with a clear cell component treated from 01 Jan 1982 to 31 Dec 2023
  • Information available (date of primary tumor diagnosis, local treatments, systemic treatment, response to systemic treatment, date of progression) and date and status at last follow-up
  • Imaging studies available for revision
  • Histological slides available for revision

Exclusion criteria

Exclusion Criteria:

  • - Diagnosis different from clear cell chondrosarcoma or chondrosarcoma with a clear cell component;
  • Absence of radiological and/or clinical data
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
77 participants (actual)

Study arms

  • Experimental
    Patients

    Patients with a diagnosis of clear cell chondrosarcoma

    Genetic: Molecular studies

Interventions

  • GeneticMolecular studies

    Molecolar studies to define possible prognostic parameters

06

What researchers measure

Primary outcomes

  1. Prognostic accuracy

    Ability of the model to predict overall survival, measured by AUC/C-index

    Time frame: At baseline

07

Study locations

1 site
  • IRCC Rizzoli Orthopedic Institute
    Bologna, 40136, Italy
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

1 registry update since Sep 25, 2026
Study completion
Jun 30, 2026→Dec 30, 2026
Nov 4, 2026
Show all 1 update
  1. Nov 4, 2026
    Study completion Jun 30, 2026→Dec 30, 2026
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07360964
Collaborators
Azienda Ospedaliero, Universitaria Pisana, Gaetano Pini CTO, Milano, IRCCS Humanitas Research Hospital, Milano, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale, Ospedale "Morgagni - Pierantoni" di Forlì, A.O.U. Città della Salute e della Scienza, Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Responsible party
Sponsor
First posted
Jan 22, 2026
Start date
Sep 10, 2025
Primary completion
Dec 31, 2025
Completion
Dec 30, 2026 (estimated)
Last update
Nov 4, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.

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