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RecruitingNCT07354048Updated Jan 21, 2026

Impact Of Thyroid Dysfunction on Liver Function Tests

An observational study in Thyroid Disease, sponsored by Sohag University. Recruiting at 1 site in Egypt. Open to participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-01-21.

Sponsored by Sohag University · Observational

From the registry’s dates

  • Primary completion was expected by Jan 2026, 9 months ago, but the record still lists the study as recruiting.
  • Started Jul 2025; still recruiting 1 year 3 months later.
Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
100
Ages
20 Years to 60 Years
Sex
All
01

Study summary

This study aims to evaluate the effect of thyroid dysfunction on liver function tests.

02

Conditions studied

  • Thyroid Disease

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03

In context

Thyroid Diseases

365 studies on the registry are indexed under Thyroid Diseases; 80 are open to participants now.

This study's planned enrollment of 100 is below the median of 198 across 158 observational studies indexed under Thyroid Diseases.

Browse Thyroid Diseases studies →

Lead sponsor

Sohag University is the lead sponsor of 1,230 studies on the registry; 636 are open to participants now.

Browse Sohag University studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • All patients between the ages of 20-60 years old either with Hypothyroidism or Hyperthyroidism (controlled on treatment or not) and firstly diagnosed Hypothyroidism or Hyperthyroidism.
  • Euthyroid controls (clinically healthy control subjects were recruited from the general population with the same socio-economic status with the subjects.)

Exclusion criteria

Exclusion Criteria:

  • Patients aged \< 20 years old.
  • Patients With Liver Disease.
  • Pregnant and lactating women.
  • Patients with severe infections or sepsis.
  • Patients with Heart Disease.
  • Patients who on drugs that can affect liver function such as phenothiazine, phenylbutazone, methyldopa, among others.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No

Groups and cohorts

  • Control group

    Other: Control group

  • Patients with hypothyroidism or hyperthyroidism that are controlled on treatment

    Other: Patients with hypothyroidism or hyperthyroidism that are controlled on treatment

  • Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment

    Other: Patients with hypothyroidism or hyperthyroidism that are not controlled on treatment

  • Patients with hypothyroidism or hyperthyroidism that are firstly discovered

    Other: Patients with hypothyroidism or hyperthyroidism that are firstly discovered

Interventions

  • OtherControl group

    Healthy people

  • OtherPatients with hypothyroidism or hyperthyroidism that are controlled on treatment

    This group includes patients with hypothyroidism or hyperthyroidism that are controlled on treatment

  • OtherPatients with hypothyroidism or hyperthyroidism that are not controlled on treatment

    This group includes patients with hypothyroidism or hyperthyroidism that are not controlled on treatment

  • OtherPatients with hypothyroidism or hyperthyroidism that are firstly discovered

    This group includes patients with hypothyroidism or hyperthyroidism that are firstly discovered

06

What researchers measure

Primary outcomes

  1. Measuring total bilirubin level in patients with thyroid dysfunction diseases

    Collecting blood samples from the patients

    Time frame: 1 months

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Boelaert K, Franklyn JA. Thyroid hormone in health and disease. J Endocrinol. 2005 Oct;187(1):1-15. doi: 10.1677/joe.1.06131. PubMed 16214936 ↗
  • Malik R, Hodgson H. The relationship between the thyroid gland and the liver. QJM. 2002 Sep;95(9):559-69. doi: 10.1093/qjmed/95.9.559. PubMed 12205333 ↗
  • Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb;23(1):38-89. doi: 10.1210/edrv.23.1.0455. PubMed 11844744 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 21, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07354048
Lead sponsor
Sohag University
Responsible party
Omnia Ahmed Mohamed Aref (Resident, Internal Medicine Department, Faculty of Medicine, Sohag University, Sohag University) — Principal investigator
First posted
Jan 21, 2026
Start date
Jul 14, 2025
Primary completion
Jan 30, 2026 (estimated)
Completion
Jan 30, 2026 (estimated)
Last update
Jan 21, 2026

Study contacts

Omnia A Mohamed, Resident
Contact
omnia_ahmed_post@med.sohag.edu.eg
01285252564
Usama M Abdel-Aal, Professor
Contact

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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