An interventional study of probiotics group and Placebo Group in Anxiety Depression, sponsored by Wecare Probiotics Co., Ltd.. Completed at 1 site in China. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-20.
Sponsored by Wecare Probiotics Co., Ltd. · Not applicable, Interventional, and Treatment
This study is a randomized, double-blind, placebo-controlled trial aimed primarily at investigating the effects of Weizmannia coagulans BC99 on alleviating anxiety and depression and the gut microbiota.
Wecare Probiotics Co., Ltd. is the lead sponsor of 65 studies on the registry; 24 are open to participants now.
Counted across the registry records on this site, refreshed daily.
5)Ability and willingness to voluntarily participate in the study and to provide written informed consent prior to enrollment.
Exclusion Criteria:
5 billion CFU/day BC99 and protein powder; Storage: sealed, protected from light, placed in a cool and dry place.
Dietary Supplement: probiotics group
Dextrin powder, 1 bags per day; Storage: sealed, protected from light, placed in a cool and dry place.
Dietary Supplement: Placebo Group
The intervention lasted 8 weeks, with follow-ups at weeks 0 and 12.
The intervention lasted 8 weeks, with follow-ups at weeks 0 and 12.
Assess the changes in the severity of depressive symptoms.
The severity of depressive symptoms is assessed by changes in scores on the Hamilton Depression Rating Scale-17 items (HAMD-17) and the Hamilton Anxiety Rating Scale (HAMA-14). The Hamilton Depression Rating Scale (17-item version) is a clinician-administered rating scale consisting of 17 items. The total score ranges from 0 to 52, with higher scores indicating more severe depressive symptoms. The Hamilton Anxiety Rating Scale (14-item version) is a clinician-administered rating scale consisting of 14 items. The total score ranges from 0 to 56, with higher scores indicating more severe anxiety symptoms.
Time frame: 8 weeks
This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Wecare Probiotics Co., Ltd.