ClinicalTrials.gg
Not yet recruitingNCT07351604Updated Mar 31, 2026

Effectiveness of Large Language Model-Based Chatbot Among Female University Stdents in Improving HPV Vaccine Awareness, Intention and Vaccination Rates

An interventional study of Scientific videos and Vaccine chatbot in HPV Vaccination Rates, HPV Vaccine Awareness and HPV Vaccination Intention, sponsored by Xiamen University. Not yet recruiting. Open to participants aged 15 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-31.

Sponsored by Xiamen University · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
18,000
Allocation
Randomized
Ages
15 Years and older
Sex
All
01

Study summary

This is an interventional study targeting female university students. The primary objective of the study is to evaluate the effectiveness of a vaccine chatbot in improving HPV vaccination rates. The secondary objectives are to evaluate the effectiveness in improving vaccine awareness and vaccination intention. All participants will be enrolled and randomly assigned to four groups: (1) vaccine chatbot plus scientific videos, (2) vaccine chatbot only, (3) scientific videos only, and (4) a control group (no intervention). The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. The scientific videos will cover content related to HPV vaccine safety, efficacy, and other relevant information. The study will compare changes in HPV vaccine awareness, vaccination intention, and vaccination behavior between the intervention groups and the control group after the intervention to evaluate whether the three intervention strategies enhance HPV vaccine awareness, vaccination intention, and vaccination uptake.

02

Conditions studied

  • HPV Vaccination Rates
  • HPV Vaccine Awareness
  • HPV Vaccination Intention

Keywords

  • HPV vaccine
  • chatbot
  • Large language model
  • AI
  • HPV vaccination
03

In context

Lead sponsor

Xiamen University is the lead sponsor of 26 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
15 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Female university students.
  2. Possess an electronic device with QR code scanning capability.
  3. Female university students have no to HPV vaccination.
  4. No mental disorders or visual/reading impairments; able to cooperate with and implement the corresponding intervention activities.
  5. Have provided and are willing to participate in the study.

Exclusion criteria

Exclusion Criteria:

-

Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
18,000 participants (estimated)

Study arms

  • Experimental
    Vaccine chatbot + Watching scientific videos group

    The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions. Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information.

    Device: Scientific videos · Device: Vaccine chatbot

  • Experimental
    Watching scientific videos group

    Scientific videos cover content related to HPV vaccine safety, efficacy, and other relevant information.

    Device: Scientific videos

  • Experimental
    Vaccine chatbot group

    The chatbot will provide immediate, validated answers to participants' HPV vaccine-related questions.

    Device: Vaccine chatbot

  • No intervention
    Control group

    No intervention

Interventions

  • DeviceScientific videos

    Provide scientific videos related to HPV vaccine

  • DeviceVaccine chatbot

    Provide vaccine chatbot to answer HPV vaccine questions

06

What researchers measure

Primary outcomes

  1. HPV vaccination rates for female university students in all groups before and after the intervention

    Whether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

    Time frame: Baseline and two months

Secondary outcomes

  1. HPV vaccine awareness for eligible female university students in all groups before and after the intervention

    A questionnaire consisting of 11 questions related to HPV vaccines will be used to investigate the awareness of HPV vaccines.Total knowledge score is calculated based on the number of questions answered correctly by the participants and the higher scores mean a better outcome.

    Time frame: Baseline and two weeks

  2. HPV vaccination intention for eligible female university students in all groups before and after the intervention

    Female university students' willingness to vaccinate themselves, measured using a five-point Likert scale from "not willing at all" to "strongly willing"

    Time frame: Baseline and two weeks

Other outcomes

  1. Vaccine chatbot acceptability and implementability

    A questionnaire consisting of 10 questions assessing usability and feasibility, fairness and safety, user experience, and overall assessment of the chatbot, measured using a five-point Likert scale from "not willing at all" to "strongly willing"

    Time frame: Two weeks

  2. Factors influencing vaccination intention for eligible female university students

    Survey items: age, education level, marital status, occupation, annual income, and awareness of vaccines.

    Time frame: Two weeks and six months

  3. HPV vaccination rates for female university students in all groups after the intervention

    Whether female university students get vaccinated against HPV or have an appointment for vaccination, measured by self-report and validated by vaccination information system

    Time frame: two weeks, one month and six months

07

Study locations

No study locations are listed for this record.

08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Apr 2026; primary completion for Dec 2027, 20 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Dec 25, 2025
First posted
Jan 20, 2026
StartEst.
Apr 1, 2026
Primary completionEst.
Dec 31, 2027
CompletionEst.
Dec 31, 2027
Last update
Mar 31, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Mar 31, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07351604
Lead sponsor
Xiamen University
Responsible party
Jun Zhang (Professor, Xiamen University) — Principal investigator
First posted
Jan 20, 2026
Start date
Apr 1, 2026 (estimated)
Primary completion
Dec 31, 2027 (estimated)
Completion
Dec 31, 2027 (estimated)
Last update
Mar 31, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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