CompletedNCT07297199Updated May 14, 2026

A Study to Learn How the Body Processes BIIB141 (Omaveloxolone) When Taken as a Capsule or as a Tablet Dissolved in Liquid, and to Learn About Its Safety in Healthy Adults Ages 18 to 55

A Phase 1 interventional study of Omaveloxolone in Healthy Volunteer, sponsored by Biogen. Completed at 1 site in United States. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-14.

Sponsored by Biogen · Phase 1, Interventional, and Treatment

Phase: Phase 1
Study type: Interventional
Enrollment: 70
Allocation: Randomized
Ages: 18 Years to 55 Years
Sex: All

Study summary

In this study, researchers will learn more about BIIB141, also known as omaveloxolone or SKYCLARYS®. This drug has been approved, or made available for doctors to prescribe, for people with Friedrich's Ataxia (FA) who are at least 16 years old. Currently, BIIB141 is taken by mouth as capsules or capsule contents sprinkled over applesauce. But, there may be some people who have trouble swallowing capsules. In this study, the main goal was to learn if BIIB141 is processed similarly in the body of healthy adults when taken as tablets that dissolve in liquid compared to the currently available capsules.

The main question researchers want to answer in this study is :

How does the body process BIIB141 when taken as a tablet dissolved in liquid compared to capsules?

Researchers will also learn more about:

How many participants have adverse events during the study. An adverse event is a health problem that may or may not be caused by the study drug.
If there are any changes in the participants' overall health during the study.

This study will be done as follows:

Participants will be screened to check if they can join the study. The screening period will be up to 28 days, after which participants will check into their study research center.
Participants will stay at the study research center for about 30 days.
This is an "open label" study. In this kind of study, the participants, study doctor, and site staff know which study drug the participant is taking. In this study, all participants will take BIIB141.
This study also has a "crossover" design. This means that all of the participants will take BIIB141, once as a tablet that dissolves in liquid and once as a capsule. But the order in which the participants take them will be different. There will be a break of about 14 days between the 2 doses.
Throughout the study, researchers will take participants' blood and urine samples. Researchers will also do other tests to check the participants' overall health and will ask participants how they are feeling.
Each participant will be in the study for up to 57 days.

Read the detailed description

The primary objective of the study is to assess the bioequivalence (BE) of omaveloxolone tablets for oral suspension (TOS) compared to capsules in healthy adult participants. The secondary objective of the study is to assess the safety and tolerability of a single dose of omaveloxolone when administered as TOS or capsule in healthy adult participants.

Conditions studied

Healthy Volunteer

In context

Lead sponsor

Biogen is the lead sponsor of 494 studies on the registry; 22 are open to participants now.

Of its 98 completed or terminated interventional studies of FDA-regulated products, 49 (50%) have results posted.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 55 Years
Sexes eligible: All
Accepts healthy volunteers: Yes

Eligibility criteria

Key Inclusion Criteria:

All female participants of childbearing potential must have negative results for pregnancy tests as follows:
1. At screening, based on a serum sample obtained within 28 days prior to initial study drug administration; and
2. Prior to dosing, based on a serum sample obtained on Study Day -1.
Body Mass Index (BMI) at screening between 18 and 32 kilograms per meter square (kg/m\^2), inclusive.
Participants must be in good health.

Key Exclusion Criteria:

History of any clinically significant cardiac, endocrine, gastrointestinal, hematologic, hepatic, immunologic, metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, or renal disease, or other major disease, as determined by the Investigator.
Clinically significant, as determined by the Investigator, 12-lead electrocardiogram (ECG) abnormalities.
History of, or positive test result for human immunodeficiency virus (HIV).
History of hepatitis C infection or positive test result at Screening for hepatitis C virus antibody (HCV Ab).
Current hepatitis B infection [defined as positive for hepatitis B surface antigen (HBsAg) and/or total hepatitis B core antibody (anti-HBc)]. Participants with immunity to hepatitis B from previous natural infection (defined as negative HBsAg, positive anti-HBc, and positive anti-HBs) or vaccination (defined as negative HBsAg, negative anti-HBc, and positive anti-HBs) are eligible to participate in the study.
Chronic, recurrent, or serious infection (e.g., pneumonia, septicemia), as determined by the Investigator, within 90 days prior to Screening or between Screening and Day -1.
Prior exposure to the study treatment.
Any clinically significant abnormal laboratory test value as determined by the Investigator, as Screening or Day-1.

NOTE: Other protocol-defined Inclusion/Exclusion criteria may apply.

Study design

Phase: Phase 1
Primary purpose: Treatment
Allocation: Randomized
Intervention model: Crossover assignment
Masking: None (open label)
Enrollment: 70 participants (actual)

Study arms

Experimental
Treatment Sequence AB
Participants will receive treatment A (omaveloxolone capsule orally) on Day 1 followed by treatment B (omaveloxolone TOS) on Day 15.
Drug: Omaveloxolone
Experimental
Treatment Sequence BA
Participants will receive treatment B (omaveloxolone TOS) on Day 1 followed by treatment A (omaveloxolone capsule orally) on Day 15.
Drug: Omaveloxolone

Interventions

DrugOmaveloxolone
Administered orally
Also known as: BIIB141, SKYCLARYS

What researchers measure

Primary outcomes

Maximum Observed Plasma Concentration (Cmax) of Omaveloxolone
Time frame: Pre-dose and at multiple timepoints post-dose up to Day 29
Area Under the Concentration-Time Curve From Time Zero Extrapolated to Infinity (AUC0-inf) of Omaveloxolone
Time frame: Pre-dose and at multiple timepoints post-dose up to Day 29

Secondary outcomes

Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)
Time frame: From Day 1 up to end of study (up to Day 29)
Number of Participants With Clinically Significant Change From Baseline in Laboratory Abnormalities
Time frame: From Day 1 up to end of study (up to Day 29)
Number of Participants With Change From Baseline in Clinically Relevant Vital Sign Abnormalities
Time frame: From Day 1 up to end of study (up to Day 29)
Number of Participants With Change From Baseline in Clinically Relevant Electrocardiogram (ECG) Abnormalities
Time frame: From Day 1 up to end of study (up to Day 29)

Study locations

1 site

Trialmed formerly PPD, Austin Clinical Research Unit
Austin, Texas 78744, United States

References and documents

Individual participant data

Plan to share: Yes — In accordance with Biogen's Clinical Trial Transparency and Data Sharing Policy on https://www.biogentrialtransparency.com/

No publications or documents are linked to this record.

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on May 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT07297199
Lead sponsor: Biogen
Responsible party: Sponsor
First posted: Dec 22, 2025
Start date: Dec 12, 2025
Primary completion: May 1, 2026
Completion: May 1, 2026
Last update: May 14, 2026

Study contacts

Medical Director

study director · Biogen

Oversight

Data monitoring committee: No
FDA-regulated drug: Yes
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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