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Active, not recruitingNCT07292311Updated Dec 18, 2025

Reliability of Muscle Strength and Activation Assessment Tools and Effects of an Online Therapeutic Exercise Program in Patients With Chronic Kidney Disease

An interventional study of Reliability Assessment and Online Therapeutic Exercise in Chronic Kidney Disease, Renal Insufficiency, Chronic and Muscle Weakness, sponsored by University of Extremadura. Active, not recruiting at 1 site in Spain. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-18.

Sponsored by University of Extremadura · Not applicable, Interventional, and Diagnostic

From the registry’s dates

  • Primary completion was expected by Jan 2026, 8 months ago, but the record still lists the study as active, not recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
50
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

This research aims to evaluate the reliability and reproducibility of muscle strength and activation measurement tools, including isokinetic dynamometry and surface electromyography, in patients with chronic kidney disease (CKD). Additionally, the study will assess the feasibility and potential benefits of an online therapeutic exercise program supervised by physiotherapists.

Read the detailed description

Patients with chronic kidney disease experience progressive muscle weakness and reduced physical capacity due to systemic inflammation, metabolic acidosis, and inactivity.

This two-phase observational and interventional study, conducted in collaboration with the ALCER Association (Badajoz and Cáceres, Spain), will:

  1. Determine the test-retest reliability of muscle assessment tools (isokinetic dynamometer, surface electromyography, and handheld dynamometry).
  2. Implement and evaluate an online therapeutic exercise program supervised by physiotherapists.

The project aims to provide valid and reliable protocols for neuromuscular assessment in CKD patients and explore the feasibility of remote therapeutic exercise.

02

Conditions studied

  • Chronic Kidney Disease
  • Renal Insufficiency, Chronic
  • Muscle Weakness
  • Sarcopenia
  • Physical Fitness
  • Physical Therapy Modalities

Keywords

  • chronic kidney disease
  • renal patients
  • muscle strength assessment
  • isokinetic testing
  • surface electromyography
  • physiotherapy
  • occupational therapy
  • functional evaluation
  • therapeutic exercise
03

In context

Renal Insufficiency, Chronic

3,144 studies on the registry are indexed under Renal Insufficiency, Chronic; 704 are open to participants now.

This study's planned enrollment of 50 is below the median of 74 across 2,176 interventional studies indexed under Renal Insufficiency, Chronic.

Browse Renal Insufficiency, Chronic studies →

Lead sponsor

University of Extremadura is the lead sponsor of 47 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • ≥18 years old.
  • Diagnosis of chronic kidney disease (hemodialysis, peritoneal dialysis, or kidney transplant).
  • Member of ALCER Association (Badajoz or Cáceres).
  • Medical clearance for physical testing/exercise.

Exclusion criteria

Exclusion Criteria:

  • Severe cognitive or communication impairment.
  • Unstable cardiovascular or musculoskeletal conditions.
  • Refusal to provide informed consent.
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
50 participants (estimated)

Study arms

  • Active comparator
    Reliability Assessment

    Test-retest reliability of isokinetic and surface EMG measurements in upper limb, trunk, and lower limb

    Device: Reliability Assessment

  • Experimental
    Online Therapeutic Exercise

    8-10 week supervised online program including resistance and mobility exercises

    Behavioral: Online Therapeutic Exercise

Interventions

  • DeviceReliability Assessment

    Device: Isokinetic dynamometer and mDurance® surface EMG Test-retest reliability of isokinetic and surface EMG measurements in upper limb, trunk, and lower limb

  • BehavioralOnline Therapeutic Exercise

    Behavioral: Online therapeutic exercise program 8-10 week supervised online program including resistance and mobility exercises

06

What researchers measure

Primary outcomes

  1. Test-retest reliability of surface EMG (Electromiography) activation.

    RMS (root mean square). microvolts

    Time frame: 7-10 days

  2. Test-retest reliability of isokinetic strength

    Intraclass Correlation Coefficient - ICC. Strength (kilograms)

    Time frame: 7-10 days

  3. Change in handgrip and limb strength measured by VALD dynamometry

    strength (kilograms)

    Time frame: Baseline and 12 weeks

07

Study locations

1 site
  • Facultad de Enfermería y Terapia Ocupacional
    Cáceres, Cáceres 10003, Spain
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 18, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07292311
Lead sponsor
University of Extremadura
Responsible party
Alejandro Caña Pino (Investigator, University of Extremadura) — Principal investigator
First posted
Dec 18, 2025
Start date
Nov 7, 2025
Primary completion
Jan 30, 2026 (estimated)
Completion
May 15, 2026 (estimated)
Last update
Dec 18, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.

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