An observational study in Sepsis in ED Patients, sponsored by Assiut University. Not yet recruiting at 1 site in Egypt. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-09.
Sponsored by Assiut University · Observational
Our goal in this work is to compare the predictive accuracy of the REDS score versus qSOFA in identifying in-hospital mortality among ED patients with suspected sepsis and improving outcomes in ED patients.
Sepsis is a life threatening condition and a major cause of morbidity and mortality in emergency department worldwide.Patients at high-risk of death may be identified by using an evidence based risk-stratification score. The ED is a busy and hard environment and any score that is used should be easy to calculate using readily available variables. The objective criteria defining sepsis, a minimum two-point increase as in qSoFA score .
The REDS (Risk-stratification of Emergency Department suspected Sepsis) score is a tool used to assess the risk of mortality in patients with suspected sepsis in the emergency department. It combines several factors including age, altered mental state, respiratory rate, systolic blood pressure, serum albumin, INR, lactate levels, and refractory hypotension. A score of 3 or more is considered high-risk. Our goal in this work is to compare the predictive accuracy of the REDS score versus qSOFA in identifying in-hospital mortality among ED patients with suspected sepsis and improving outcomes in ED patients.
The REDS score includes the following variables, each assigned a point value:
Age: ≥ 65 years old (1 point) Altered Mental State: (1 point) Respiratory Rate: ≥ 22 breaths/min (1 point) Systolic Blood Pressure: ≤ 100 mm Hg (1 point) Serum Albumin: ≤ 27 g/L (1 point) INR: ≥ 1.3 (1 point) Lactate: 2.1-3.9 mmol/L (1 point), ≥ 4 mmol/L (3 points) Refractory Hypotension: (2 points for lactate ≤ 2 mmol/L, 3 points for lactate >2 mmol/L)
Interpreting the REDS score:
0-2: Low risk of death 3 or more: High risk of death The REDS score is a useful tool for emergency departments to quickly identify patients who may be at higher risk of mortality from sepsis and need more aggressive or immediate treatment.The quick SOFA (qSOFA) score is a bedside tool used to quickly assess the risk of death or prolonged intensive care unit stay in patients with suspected infection. It uses three criteria: respiratory rate, altered mental status, and systolic blood pressure. A score of 2 or more indicates a higher risk.
qSOFA Criteria:
Scoring:
Each criterion met scores 1 point. A score of 2 or more indicates a higher risk of poor outcome. qSOFA helps identify patients with suspected infection who are likely to have sepsis. It is a rapid assessment tool that can be used in urgent and resource-limited settings
Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
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Our goal in this work is to compare the predictive accuracy of the REDS score versus qSOFA in identifying in-hospital mortality among ED patients with suspected sepsis and improving outcomes in ED patients.
Exclusion Criteria:
Patients will be randomly assigned to two groups: 1. Group A: Initial vital signs upon arrival at ED triage to evaluate the REDS score \[ Time Frame: Timepoint 0 (ED triage) Age: ≥ 65 years old (1 point) Altered Mental State: (1 point) \[from 1-15\] Respiratory Rate: ≥22 breaths/min (1point ) \[yes or not\] Systolic Blood Pressure: ≤100 mm Hg (1 point) \[yes or not\] Serum Albumin: ≤27 g/L (1 point) \[yes or not\] INR: ≥1.3 (1 point)\[yes or not\] Lactate: 2.1-3.9 mmol/L (1 point), ≥4 mmol/L (3 points) Refractory Hypotension: (2 points for lactate ≤2 mmol/L, 3 points for lactate \>2 mmol/L) will be assessed to evaluate the REDS score. 2. Group B: Initial vital signs upon arrival at ED triage to evaluate the qSOFA score \[ Time Frame: Timepoint 0 (ED triage) \] . * Respiratory rate per minute * Mental status * Systolic blood pressure.
Device: Sphygmomanometer
Mercury sphygmomanometer for measuring blood pressure
Primary outcome
primary outcome will be mortality during the 30 day follow-up
Time frame: 30 day
This study is not yet recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Assiut University