An interventional study of "Autogenous Tooth Bone Graft" in Alveolar Bone Grafting, Bone Regeneration Following Wisdom Teeth Extraction and Tooth Extraction Site Healing, sponsored by Haifaa Mohammed Al-hussini. Active, not recruiting at 1 site in Yemen. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-05.
Sponsored by Haifaa Mohammed Al-hussini · Not applicable, Interventional, and Treatment
The purpose of this clinical experiment is to assess how well autogenous tooth bone grafting preserves the alveolar socket after surgical tooth extraction. Before being inserted into the socket, the graft is made from the patient's own extracted tooth and ground into a particle. Twenty Yemeni patients who needed their teeth extracted are included in the trial, and they will be followed up with clinical and radiographic procedures using cone-beam computed tomography (CBCT) for six months. The primary objective is to ascertain whether the autogenous dental bone graft can preserve the height, width, and density of alveolar bone, offering a secure, affordable, and biocompatible substitute for traditional grafting materials.
This interventional clinical study investigates the role of autogenous tooth bone graft in alveolar socket preservation after surgical tooth extraction. The extracted tooth is cleaned, dried, processed into particulate graft material manually using bone crusher, and disinfect and treated using (NaOH) and (Na CL). The graft particles are immediately placed into the fresh extraction socket and sutured. Twenty Yemeni patients requiring impacted lower third molar and upper canine teeth surgical extractions will be included. The healing process will be evaluated both clinically and radiographically over a 6-month period. Cone-beam computed tomography (CBCT) scans will be used to assess bone density and alveolar ridge dimensions before extraction and at six months' post-intervention. The study aims to determine whether autogenous tooth bone grafts can effectively reduce post-extraction alveolar bone resorption and maintain ridge dimensions, supporting their potential use as an autologous, biocompatible, and economically feasible graft material for clinical socket preservation.
This is the only study on the registry with Haifaa Mohammed Al-hussini as lead sponsor.
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"In this arm of the study, participants will receive an autogenous tooth bone graft for alveolar socket preservation following surgical tooth extraction. The intervention involves the extraction of the patient's own tooth, which will be processed and used as a bone graft. This graft will be placed into the empty socket immediately after the extraction. The purpose of this intervention is to prevent bone resorption, promote natural healing, and support bone regeneration within the extraction site. CBCT scans will be performed before extraction to measure baseline bone dimensions and will be repeated 6 months post-intervention to assess the success of bone preservation in terms of height, width, and density."
Biological: "Autogenous Tooth Bone Graft"
"The intervention involves the use of the patient's own extracted tooth to create a bone graft for alveolar socket preservation following surgical tooth extraction. The patient's tooth is carefully processed to remove caries, periodontal ligaments, pulp, and any restorative materials, leaving behind a complete tooth structure (enamel, dentin, and cementum). This tooth is then crushed, disinfected, and treated before being placed into the empty socket. This graft helps maintain the structure of the alveolar bone by promoting natural bone regeneration and preventing resorption. The bone graft will be monitored for its efficacy in preserving alveolar bone height, width, and density, assessed using Cone Beam Computed Tomography (CBCT)."
"Alveolar Bone Height, Width, and Density Preservation with Autogenous Tooth Bone Graft"
This study aims to evaluate the effectiveness of autogenous tooth bone grafts in preserving alveolar bone following tooth extraction. The study will assess changes in alveolar bone height, width, and density using Cone Beam Computed Tomography (CBCT) at two time points: before extraction (baseline) and 6 months post-grafting. The outcome measures are: Alveolar Bone Height: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Width: Measured in millimeters using CBCT at baseline and 6 months. Alveolar Bone Density: Measured in Hounsfield units using CBCT at both time points. The intervention involves using the patient's own extracted tooth to create a bone graft placed into the socket, promoting healing and bone regeneration. This study will determine the effectiveness of autogenous tooth bone grafts in preventing bone resorption and preserving alveolar socket structure.
Time frame: "Before extraction and 6 months post-intervention"
Plan to share: Yes — "We will share anonymized individual participant data (IPD), including baseline characteristics, clinical assessments, and key outcome measures (alveolar bone height, width, and density) collected before and after the autogenous tooth bone graft intervention. Access to the data will be granted to qualified researchers who meet the criteria for data sharing and comply with the applicable data use agreement."
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: "IPD and supporting information will be made available starting 12 months after the completion of the study. The data will be accessible for a period of 5 years."
Access criteria: "Access to IPD and supporting information will be granted to qualified researchers who submit a data request via the ClinicalTrials.gov platform. Researchers must meet the criteria outlined in the Data Use Agreement, which ensures that the data will be used responsibly and for research purposes only."
Data sharing details ↗ · clinicaltrials.gov
Ran from Jul 2024 to primary completion in Nov 2025, 15 months.
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