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CompletedNCT07257874Updated May 15, 2026

Intraoperative Pectoral Block vs IV Analgesia for Pain After Modified Radical Mastectomy

A Phase 3 interventional study of bupivacaine 0.5% injection and Ketorolac 30 mg IV in Mastectomy, Modified Radical, sponsored by Islamabad Medical and Dental College. Completed at 1 site in Pakistan. Open to female participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-05-15.

Sponsored by Islamabad Medical and Dental College · Phase 3, Interventional, and Other

From the registry’s dates

  • Registered 4 months after the study started (first participant enrolled Jul 2025, registered Nov 2025).
Phase
Phase 3
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
Female
01

Study summary

There is difference in post operative pain between patients receiving inter- pectoral block and those receiving standard Intravenous analgesia(INJ TORADOL) in patients undergoing Modified Radical Mastectomy.

To compare between these two methods , which one is better for post operative pain management.

02

Conditions studied

  • Mastectomy, Modified Radical
03

In context

Lead sponsor

Islamabad Medical and Dental College is the lead sponsor of 14 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • Female Patients undergoing Modified Radical Mastectomy for biopsy proven Carcinoma Breast
  • Patient with age 18-65 years
  • Patients with ASA Grade 2
  • BMI less than 40 kg/meter square

Exclusion criteria

Exclusion Criteria:

  • Block site infection
  • Coagulopathies (INR > 1.6 and Platelets \< 100000)
  • Any Organ dysfunction such as severe cardiac, pulmonary, renal or liver dysfunction
  • Systemic infection
  • Dementia
  • Known hypersensitivity to local anesthetic agents
05

Study design

Phase
Phase 3
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    PECs Arm

    Drug: bupivacaine 0.5% injection

  • Active comparator
    IV Analgesia Arm

    Drug: Ketorolac 30 mg IV

Interventions

  • Drugbupivacaine 0.5% injection

    Intra-Operative Pectoral Block in Patients Undergoing Modified Radical Mastectomy for Post operative Pain management

  • DrugKetorolac 30 mg IV

    Ketorolac 30mg administered Intravenously as a standard practice for post operative pain management in modified radical mastectomy

06

What researchers measure

Primary outcomes

  1. Postoperative Pain Severity at 24 hours Measured by Numeric Pain Rating Scale from 0-10 , where 0 is no pain and 10 is severe pain.

    Time frame: 24 hours Post Surgery

07

Study locations

1 site
  • Akbar Niazi Teaching Hospital
    Islamabad, 44000, Pakistan
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 15, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07257874
Lead sponsor
Islamabad Medical and Dental College
Responsible party
Sponsor
First posted
Dec 2, 2025
Start date
Jul 1, 2025
Primary completion
Dec 15, 2025
Completion
Dec 15, 2025
Last update
May 15, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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