An observational study in Bone Density and Gut Microbiomes, sponsored by Jianhua Ma. Completed at 1 site in China. Open to participants aged 6 Years to 13 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-05.
Sponsored by Jianhua Ma · Observational
The study aims to understand the current situation of bone health in the Gannan Tibetan primary school student population, to explore the relationship between nutrition, intestinal microorganisms and bone health, to analyze the main factors affecting bone health from the perspective of nutrition and intestinal microecology, and to provide theoretical basis for the promotion and improvement of bone health in Tibetan primary school students.
Jianhua Ma is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
This study is based on a cross-sectional design. Two schools were selected: one rural primary school in Xiahe County, Gannan Tibetan Autonomous Prefecture, and one urban primary school in Hezuo City, Gansu Province. Within the selected schools, a stratified random cluster sampling method was used to randomly select one class from each grade as the study subjects.
Inclusion Criteria:
Willing to participate and able to cooperate in completing bone density measurements;
Additional inclusion criteria: Subjects who are 9 years old or older and agree to participate in dietary surveys and fecal sampling.
Exclusion Criteria:Use of corticosteroid medications within the past year;
Suffering from skeletal system diseases, metabolic disorders, or endocrine diseases;
Additional exclusion criteria: Subjects who have used antibiotics in the past three months and are undergoing fecal sampling.
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Other: No Intervention: Observational Cohort
No Intervention
Dietary Characteristics
Dietary data were collected using a food frequency questionnaire (FFQ) to analyze dietary patterns and nutrient intake.
Time frame: Day 1
Bone density test
In this study, a peripheral dual-energy X-ray absorptiometry (EXA-PRESTO) was used to measure the bone density of the non-dominant forearm of the subjects.
Time frame: Day1
Fecal sample microbiological testing and analysis
This study entrusted Tianhao Gene Technology Co., Ltd. to perform the intestinal microbiome Accu16STM (16S rRNA absolute quantitative sequencing). The main research processes include DNA extraction, PCR amplification, library construction, and sequencing.
Time frame: Day 1
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Jianhua Ma