An interventional study of Structured Breathing in Burnout, Healthcare Workers and Breathing Exercises, sponsored by Mayo Clinic. Recruiting at 4 sites in United States. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-05.
Sponsored by Mayo Clinic · Not applicable, Interventional, and Treatment
The purpose of this study is to assess the immediate and long-term effects of structured breathing on clinical symptoms related to mental health including anxiety, depression, perceived stress, and sleep quality.
442 studies on the registry are indexed under Burnout, Psychological; 106 are open to participants now.
This study's planned enrollment of 40 is below the median of 80 across 319 interventional studies indexed under Burnout, Psychological.
Browse Burnout, Psychological studies →Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Engaging in self-guided breathing sessions to improve brain circulation and mental well-being.
Behavioral: Structured Breathing
15, 30, or 36 minute structured breathing sessions based on personal skill level.
Assess feasibility of the structured breathing-based intervention among healthcare professionals via ease of recruitment
This outcome measure will assess whether the structured breathing-based intervention is feasible among healthcare professionals via ease of recruitment reported by study staff.
Time frame: Enrollment to end of study participation at 4 months.
Assess feasibility of the structured breathing-based intervention among healthcare professionals via retention statistics
This outcome measure will assess the feasibility of the structured breathing-based intervention among healthcare professionals by examining retention rates throughout study duration.
Time frame: Enrollment to end of study participation at 4 months
Assess feasibility of the structured breathing-based intervention among healthcare professionals via mobile app engagement metrics
This outcome measure will assess whether the structured breathing-based intervention is feasible among healthcare professionals by analyzing app usage metrics from participants.
Time frame: Enrollment to end of study participation at 4 months
Assess feasibility of structured breathing-based intervention among healthcare professionals via Feasibility of Intervention Measure
To assess the feasibility of a structured breathing intervention among healthcare professionals using Feasibility of Intervention Measure (FIM). Feasibility of Intervention Measure is a four-item measure of implementation feasibility with scores ranging from 1-5, with higher scores indicating greater feasibility.
Time frame: Enrollment to end of study participation at 4 months
Assess appropriateness of structured breathing-based intervention among healthcare professionals
To assess the appropriateness of a structured breathing intervention among healthcare professionals using Intervention Appropriateness Measure (IAM). Intervention Appropriateness Measure is a four-item measure with a scale of responses from 1-5, with higher scores indicating greater appropriateness.
Time frame: Enrollment to end of study participation at 4 months
Assess acceptability of structured breathing-based intervention among healthcare professionals
To assess the acceptability of a structured breathing intervention among healthcare professionals utilizing the Acceptability of Intervention Measure (AIM). Acceptability of Intervention Measure is a four-item measure with responses from 1-5, with higher scores equating to greater acceptability.
Time frame: From enrollment to the end of study participation at 4 months
Assess participant satisfaction related to breathing-based intervention
Participant satisfaction will be assessed through a mixed-methods approach combining quantitative surveys (exit survey) and qualitative participant interviews (4 month in-person visit/interview).
Time frame: Enrollment to end of study participation at 4 months.
Evaluate intervention adherence, usability, and engagement metrics via mobile application
To evaluate the breathing intervention adherence, usability, and engagement metrics collected through the mobile application platform. These data will be used to identify barriers and facilitators to digital engagement, assess usability, and inform refinements to the intervention's delivery and technological infrastructure for future large-scale trials.
Time frame: Enrollment to end of treatment at 4 months.
Assess the physiological effects of the breathing-based intervention
As an exploratory objective, the study will assess the physiological effects of the breathing-based intervention on cerebral oxygenation and local tissue hemodynamics, utilizing functional near-infrared spectroscopy (fNIRS) data performed pre-and-post intervention.
Time frame: Enrollment to end of intervention at 4 months. Additional assessments during data analysis period.
Assess the psychological effects of the breathing-based intervention
The psychological effects and outcomes will be assessed, using questionnaires completed at specific timepoints throughout the study. Questionnaires to include General Health Questionnaire (GHQ), Copenhagen Burnout Inventory (CBI), Generalized Anxiety Disorder scale (GAD), Perceived Stress Scale (PSS), Brief Resilience Scale (BRS).
Time frame: Enrollment to end of intervention at 4 months. Additional assessments during data analysis period
Assess feasibility of collecting physiological and psychological data
This exploratory analysis is intended to assess the feasibility of collecting physiological and psychological data from participants, as reported by study staff who are assigned to collect this data.
Time frame: Enrollment to end of study participation at 4 months.
Assess gathered data to apply to future research
This exploratory analysis will examine study data to identify preliminary trends that can inform the design and power calculations of future definitive trials.
Time frame: Data analysis period after data collection is complete
Plan to share: No
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