An interventional study of MRI and Psychometric in Amnesia and Memory Disorder, sponsored by University Hospital, Toulouse. Recruiting at 2 sites in France. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-08.
Sponsored by University Hospital, Toulouse · Not applicable, Interventional, and Other
THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.
The preservation of learning abilities is an essential aspect in the implementation of cognitive rehabilitation programs for patients with an amnesic syndrome. Particularly disabled on a daily basis, these patients have significant difficulties in coping with the demands of work and family life. Data from previous case studies attest to the ability of these patients to rely on preserved cognitive systems to learn new semantic information. However, the procedures for the acquisition of new information are sometimes long, not optimal and the clinical factors, that can influence it, are poorly identified. In addition, the brain networks necessary for such learning are still debated. In order to better understand the cognitive mechanisms and brain networks that underlie the ability to learn new semantic information, the research aims to study a group of patients with major memory impairment following medial temporal lobe lesions of various etiologies (non-degenerative). The study will use a combined psychometric and neuroimaging approach to identify the factors that enable these patients to successfully learn new semantic information.
22 studies on the registry are indexed under Amnesia; 2 are open to participants now.
This study's planned enrollment of 150 is above the median of 62 across 19 interventional studies indexed under Amnesia.
Browse Amnesia studies →University Hospital, Toulouse is the lead sponsor of 807 studies on the registry; 209 are open to participants now.
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1 MRI session, 2 cognitive research tasks of semantic learning, and neuropsychological assessment.
Other: MRI · Other: Psychometric
To allow multiple pairing for each patient, a group of 120 healthy controls aged between 18 to 70 years old will be recruited. Thus, it will be possible to compare one given patient to a group of 40 aged-matched subjects. All healthy volunteers will undergo the same intervention as the patients : 1 MRI session, 2 cognitive research tasks of semantic learning, neuropsychological assessment.
Other: MRI · Other: Psychometric
structural and functional resting state MRI
2 cognitive research tasks of semantic learning and neuropsychological assessment
Performance on Fast-Mapping semantic learning task
* MRI measures: Anatomical MRI (T1-weighted) images will be analyzed using voxel-based lesion-symptom mapping (VLSM, MATLAB toolbox). Voxels will be classified as "lesioned" or "non-lesioned" in gray and white matter. * Behavioral measures: Performance on fast-mapping tasks (recognition scores). Those measurements will be aggregated : VLSM will be used to generate statistical maps of significant differences in fast-mapping recognition scores between lesioned vs. non-lesioned voxels across the T1 MRI. This method allows the evaluation of statistical relationships between specific brain lesions and behavioral deficits without requiring patient grouping by lesion site or behavioral threshold. VLSM integrates permutation testing for robust statistical inference and can analyze both discrete and graded lesions. As voxels may be located in either cortical or white matter regions, the approach enables the investigation of disconnection syndromes in addition to cortical syndromes.
Time frame: Baseline
Performance of semantic learning
The performance of semantic learning during social interactions will be compared to another condition without social interactions. A correlation between the time elapsed since the brain injury and the performance on semantic learning tasks will be assessed. The effect of the localisation of the lesions (hippocampal or extra-hippocampal) will be determined.
Time frame: Baseline
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