An interventional study of RIPerC and RIPC in Acute Myocardial Infarction, sponsored by Henan Institute of Cardiovascular Epidemiology. Recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-18.
Sponsored by Henan Institute of Cardiovascular Epidemiology · Not applicable, Interventional, and Treatment
At present, there are 290 million cardiovascular patients in China, including 11 million patients with coronary heart disease. Remote ischemic preconditioning(RIPC) may play an effective endogenous cardiac protection.This study will explore whether long-term use of RIPC in patients with AMI after PCI and non interventional therapy can reduce the incidence of major adverse cardiovascular cerebrovascular events(MACCE) and improve clinical outcomes and long-term prognosis.
A total of 2146 patients with AMI are expected included as the research objects and randomly divided into experimental group and control group with 1073 cases in each group. After admission, Patients in the experimental group received everyday RIPC of upper limbs to the end of follow-up.The control group is a blank control and undergoes conventional medical procedures. Routine blood indexes, ultrasound, electrocardiogram, were detected On the day of admission. 12 months post- discharge, the incidence of MACCE(include Cardiovascular death, non-fatal acute myocardial infarction, stent thrombosis, revascularization, stroke, admission due to heart failure and the above composite events were independent components) and Poce(All deaths, all strokes, all myocardial infarction, or all revascularization events)will recorded by telephone follow-up.
Henan Institute of Cardiovascular Epidemiology is the lead sponsor of 29 studies on the registry; 12 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Remote ischemic PERconditioning was initiated immediately after the diagnosis of acute myocardial infarction， and Remote ischemic PREconditioning was performed daily after discharge
Other: RIPerC · Other: RIPC
Remote ischemic PERconditioning was initiated immediately after the diagnosis of acute myocardial infarction
Other: RIPerC
A group of patients who received conventional treatment without any additional intervention
Each 40 minutes treatment time, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles
Each 40 minutes treatment time, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles
Rate of MACCEs
MACCE(include Cardiovascular death, non-fatal acute myocardial infarction, revascularization, stroke, admission due to heart failure )
Time frame: 12 months after discharge
Rate of Cardiovascular death events
Rate of Cardiovascular death events
Time frame: 12 months after discharge
Rate of non-fatal acute myocardial infarction events
Rate of non-fatal acute myocardial infarction events
Time frame: 12 months after discharge
Rate of revascularization events
Rate of revascularization events
Time frame: 12 months after discharge
Rate of stroke events
Rate of stroke events
Time frame: 12 months after discharge
Rate of admission due to heart failure events
Rate of admission due to heart failure events
Time frame: 12 months after discharge
Rate of all all-cause death events
Rate of all all-cause death events
Time frame: 12 months after discharge
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Henan Institute of Cardiovascular Epidemiology