An observational study in Periodontal Inflammation, Biofilm and Endothelial Dysfunction, sponsored by Istanbul Saglik Bilimleri University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 25 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-01-30.
Sponsored by Istanbul Saglik Bilimleri University · Observational
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.
Istanbul Saglik Bilimleri University is the lead sponsor of 58 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Endearterectomy diagnosed, dentate and edentulous patients
Exclusion Criteria:
Other: atheroma plaque · Other: Dental plaque
Before the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.
Subgingival plaque samples will be collected from patients before the endarterectomy procedure.
Bacterial frequency (%)
The percentage of bacteria in the red complex in atheroma plaque and dental plaque is evaluated using polymerase chain reaction methods.
Time frame: Months 6-9 of the study
Changes in mtDNA copy number (number)
Evaluation by means of quantitative polymerase chain reaction of mtDNA copy number in atheroma plaque
Time frame: Months 6-9 of the study
periodontal healths (mm)
Evaluation by means of periodontal indices such as PI, GI, BOP, PD.
Time frame: 8 months
Plan to share: No
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Istanbul Saglik Bilimleri University