An interventional study of Oral phosphate load in Aging, Kidney Disease and Mineral Metabolism, sponsored by University of Zurich. Not yet recruiting. Open to participants aged 25 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-02.
Sponsored by University of Zurich · Not applicable, Interventional, and Basic science
Kidney function declines with age and this could affect phosphate balance after an acute phosphate load (increased phosphate intake). In daily life, we regularly experience acute phosphate loads through our diet.
The aim of this clinical study is to determine whether the body's response to increased phosphate intake changes with age and whether there are sex differences in this response.
Forty subjects (males and females aged 18-25 or 63-70) will ingest an oral phosphate load, after which their body's response will be assessed by collecting blood and urine samples over a period of ten hours.
3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.
This study's planned enrollment of 40 is below the median of 70 across 2,640 interventional studies indexed under Kidney Diseases.
Browse Kidney Diseases studies →University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.
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Exclusion Criteria:
Intake of vitamin D and calcium supplements, phosphate, bisphosphonates, cinacalcet, denusomab, teriparatide, systemic glucocorticoids or mineralcorticoids, antiepileptics, carboanydrase inhibitors or diuretics
Participants will eat a standard phosphate dinner. The next morning, after consuming a standard phosphate breakfast, they will ingest a phosphate load (558 mg phosphorus) and provide blood and urine samples for nine hours.
Other: Oral phosphate load
Participants ingest an oral phosphate load containing 558 mg of phosphorus once.
Phosphate in plasma
Phosphate in plasma 4 hours after the oral phosphate load shows age differences
Time frame: The primary outcome will be measured 5 hours after the first blood collection on the day of the study and 4 hours after ingesting the oral phosphate load.
No study locations are listed for this record.
This study is not yet recruiting, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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University of Zurich