ClinicalTrials.gg
RecruitingNCT07113405ITMVC-DJUpdated May 4, 2026

Influence of Tea Extract on Maximal Voluntary Knee Contraction Following Downhill Jogging

An interventional study of Protein and tea extract and Protein in Muscle Recovery, sponsored by University of Fribourg. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-04.

Sponsored by University of Fribourg · Not applicable, Interventional, and Basic science

From the registry’s dates

  • Started Dec 2025; still recruiting 11 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 40 Years
Sex
All
01

Study summary

In this research project, we want to investigate whether the combined intake of proteins and tea extract has an influence on muscle regeneration compared to the sole intake of proteins or a placebo product. In the study, you will be randomly assigned to one of 3 groups. Neither the research group nor you will know which group you are assigned to. The study lasts 5 days for you as a participant. During these 5 days you will have to attend a total of 5 appointments in our laboratory. The groups differ only in the intake of the regeneration product, otherwise all measurements and appointments are identical. You will jog downhill for 30 minutes on the first day in order to strain your muscles. In order to be able to draw conclusions about the regeneration of your muscles, we will carry out the following measurements on all 5 days: Blood sampling at the fingertip, ultrasound of the thigh muscle, pain tolerance of the thigh muscle, strength tests of the thigh muscle, muscle function of the thigh muscle and jumping performance.

02

Conditions studied

  • Muscle Recovery

Keywords

  • Protein
  • muscle recovery
  • Tea extract
  • EIMD
03

In context

Lead sponsor

University of Fribourg is the lead sponsor of 16 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Signed written
  • Aged between 18-40 years
  • Healthy subjects

Exclusion criteria

Exclusion Criteria:

  • Any type of food allergy (e.g. nuts)
  • Health-related problems according to the "Physical Activity Readiness Questionnaire (PAR-Q)
  • Current injury of the lower extremities
  • Serious clinical back pain or current back injuries
  • Orthopedic disorders
  • Cardiovascular diseases
  • Current Intake of blood-thinning medication
  • Current Intake of anti-inflammatory medication
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
60 participants (estimated)

Study arms

  • Experimental
    Protein and tea extract

    This group will receive a recovery drink containing protein and tea extract.

    Dietary Supplement: Protein and tea extract

  • Active comparator
    Protein

    This group will receive a recovery drink containing protein without tea extract.

    Dietary Supplement: Protein

  • Placebo comparator
    Placebo

    This group will receive a recovery drink containing a placebo product. The placebo product is a non-isoenergetic, non-protein, artificially flavoured liquid.

    Dietary Supplement: Placebo

Interventions

  • Dietary supplementProtein and tea extract

    Drug pages: Proteins · Tea

    Participants in this group will receive 4 times a recovery drink containing protein and tea extract.

  • Dietary supplementProtein

    Participants of this group will receive ten times a recovery drink containing only protein without tea extract.

  • Dietary supplementPlacebo

    Participants of this group will receive 10 times a placebo containing no protein nor tea extract.

06

What researchers measure

Primary outcomes

  1. Change in maximum knee extension force immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.

    The maximal force is measured in Nm while the participant is seated on an isokinetic device.

    Time frame: 5 days

  2. Change in jump performance immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.

    The jump performance is measured in cm while the participant are performing counter movement jumps.

    Time frame: 5 days

  3. Change in perceived pain immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.

    Perceived pain is measured in Pa while the participant is seated on the isokinetic device. The measurement point is on vastus medialis muscle.

    Time frame: 5 days

  4. Change in muscle thickness immediately after training-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.

    Muscle thickness is measured with b-mode ultrasound in mm while the participant is sitting on the isokinetic device. The measurement point is on the vastus medialis muscle.

    Time frame: 5 days

  5. Change in creatine kinase levels immediately after exercise-induced muscle damage and 24, 48, 72, and 96 hours thereafter compared to baseline.

    Creatine kinase is measured in U/L and determined using a capillary finger blood sample of 0.25 ml.

    Time frame: 5 days

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Volpe-Fix AR, de Franca E, Silvestre JC, Thomatieli-Santos RV. The Use of Some Polyphenols in the Modulation of Muscle Damage and Inflammation Induced by Physical Exercise: A Review. Foods. 2023 Feb 21;12(5):916. doi: 10.3390/foods12050916. PubMed 36900433 ↗
  • Isaacs AW, Macaluso F, Smith C, Myburgh KH. C-Reactive Protein Is Elevated Only in High Creatine Kinase Responders to Muscle Damaging Exercise. Front Physiol. 2019 Feb 11;10:86. doi: 10.3389/fphys.2019.00086. eCollection 2019. PubMed 30804809 ↗
  • Hug F, Avrillon S, Del Vecchio A, Casolo A, Ibanez J, Nuccio S, Rossato J, Holobar A, Farina D. Analysis of motor unit spike trains estimated from high-density surface electromyography is highly reliable across operators. J Electromyogr Kinesiol. 2021 Jun;58:102548. doi: 10.1016/j.jelekin.2021.102548. Epub 2021 Mar 30. PubMed 33838590 ↗
  • Fischer AA. Pressure algometry over normal muscles. Standard values, validity and reproducibility of pressure threshold. Pain. 1987 Jul;30(1):115-126. doi: 10.1016/0304-3959(87)90089-3. PubMed 3614975 ↗
  • Del Vecchio A, Casolo A, Negro F, Scorcelletti M, Bazzucchi I, Enoka R, Felici F, Farina D. The increase in muscle force after 4 weeks of strength training is mediated by adaptations in motor unit recruitment and rate coding. J Physiol. 2019 Apr;597(7):1873-1887. doi: 10.1113/JP277250. Epub 2019 Feb 6. PubMed 30727028 ↗
  • Coratella G, Varesco G, Rozand V, Cuinet B, Sansoni V, Lombardi G, Vernillo G, Mourot L. Downhill running increases markers of muscle damage and impairs the maximal voluntary force production as well as the late phase of the rate of voluntary force development. Eur J Appl Physiol. 2024 Jun;124(6):1875-1883. doi: 10.1007/s00421-023-05412-z. Epub 2024 Jan 10. PubMed 38195943 ↗
  • Botter A, Vieira TM, Loram ID, Merletti R, Hodson-Tole EF. A novel system of electrodes transparent to ultrasound for simultaneous detection of myoelectric activity and B-mode ultrasound images of skeletal muscles. J Appl Physiol (1985). 2013 Oct 15;115(8):1203-14. doi: 10.1152/japplphysiol.00090.2013. Epub 2013 Aug 1. PubMed 23908313 ↗

Individual participant data

Plan to share: No — It is planned that only our research group will analyze and publish the data. Therefore, the data will not be passed on to other researchers.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07113405
Lead sponsor
University of Fribourg
Responsible party
Sponsor
First posted
Aug 8, 2025
Start date
Dec 1, 2025
Primary completion
Dec 30, 2026 (estimated)
Completion
Dec 30, 2026 (estimated)
Last update
May 4, 2026

Study contacts

Sven Egger, Dr.
Contact
sven.egger@unifr.ch
+41 26 300 72 85
Benedikt Lauber, PD Dr.
Contact
benedikt.lauber@unifr.ch
+41 26 300 72 86

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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Studies of the drugs tested here: Proteins · Tea

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