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CompletedNCT07083128Updated Mar 25, 2026

Temporal Change in Parasternal Thickening Fraction as a Predictor for Weaning

An observational study in Mechanical Ventilation, Weaning From Mechanical Ventilation and Weaning Failure, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-03-25.

Sponsored by Cairo University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
64
Ages
18 Years to 65 Years
Sex
All
01

Study summary

optimal time to liberate from mechanical ventilation is highly prioritized since improper extubation time lead to serious consequences

Read the detailed description

Several parameters were proposed to assess proper weaning time including diaphragmatic ultrasound and extra-diaghragmatic muscles. previous research concluded an ability of parasternal intercostal (PIC) thickening to predict weaning outcomes. researchers of current study assumed that temporal changes in PIC thickening would provide greater ability to predict weaning outcomes

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Conditions studied

  • Mechanical Ventilation
  • Weaning From Mechanical Ventilation
  • Weaning Failure

Keywords

  • Parasternal thickening; failed weaning; extubation
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In context

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Adult patient who are mechanically ventilated for 24 hours or more and ready for weaning

Inclusion criteria

- Mechanically ventilated for 24 hours or more ready for weaning

Exclusion criteria

Exclusion Criteria:

  • Refusal Tracheostomized Inability to obtain ultrasound views patients with neuromuscular disease
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
64 participants (actual)
Patient registry
No

Interventions

  • DeviceParasternal intercostal thickening

    Temporal change in parasternal intercostal thickening fraction at initiation and 30 minutes of spontaneous breathing trial

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What researchers measure

Primary outcomes

  1. Accuracy of change in PIC-TF in predicting successful weaning from mechanical ventilation

    percentage of change in PIC TF in predicting weaning outcome (PIC TF30-PIC TF0)

    Time frame: At baseline and 30 minutes after initiation of spontaneous breathing trial

Secondary outcomes

  1. Accuracy of change in PIC-TF to predict reintubation

    percentage of change in PIC TF at start and end of spontaneous breathing trial (PIC TF30-PIC TF0)

    Time frame: At baseline and 30 minutes after initiation of spontaneous breathing trial

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Study locations

1 site
  • Cairo University
    Cairo, Cairo Governorate 6890, Egypt
08

References and documents

Publications

  • Helmy MA, Hasanin A, Milad LM, Mostafa M, Hamimy WI, Muhareb RS, Raafat H. Ability of parasternal intercostal muscle thickening fraction to predict reintubation in surgical patients with sepsis. BMC Anesthesiol. 2024 Aug 22;24(1):294. doi: 10.1186/s12871-024-02666-8. PubMed 39174907 ↗
  • Helmy MA, Milad LM, Hasanin AM, Mostafa M, Mannaa AH, Youssef MM, Abdelaziz M, Alkonaiesy R, Elshal MM, Hosny O. Parasternal intercostal thickening at hospital admission: a promising indicator for mechanical ventilation risk in subjects with severe COVID-19. J Clin Monit Comput. 2023 Oct;37(5):1287-1293. doi: 10.1007/s10877-023-00989-4. Epub 2023 Mar 24. PubMed 36961635 ↗
  • Helmy MA, Hasanin A, Milad LM, Mostafa M, Fathy S. Parasternal intercostal muscle thickening as a predictor of non-invasive ventilation failure in patients with COVID-19. Anaesth Crit Care Pain Med. 2022 Jun;41(3):101063. doi: 10.1016/j.accpm.2022.101063. Epub 2022 Apr 26. No abstract available. PubMed 35487407 ↗
  • Helmy MA, Magdy Milad L, Osman SH, Ali MA, Hasanin A. Diaphragmatic excursion: A possible key player for predicting successful weaning in patients with severe COVID-19. Anaesth Crit Care Pain Med. 2021 Jun;40(3):100875. doi: 10.1016/j.accpm.2021.100875. Epub 2021 Apr 30. No abstract available. PubMed 33940248 ↗
  • Adolf Helmy M, Magdy Milad L, Hasanin A, Mostafa M. The novel use of diaphragmatic excursion on hospital admission to predict the need for ventilatory support in patients with coronavirus disease 2019. Anaesth Crit Care Pain Med. 2021 Dec;40(6):100976. doi: 10.1016/j.accpm.2021.100976. Epub 2021 Nov 5. PubMed 34748940 ↗

Individual participant data

Plan to share: Undecided — IPD may not be shared due to confidentiality, legal constraints, or the need to protect intellectual property rights.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07083128
Lead sponsor
Cairo University
Responsible party
Mina Adolf Helmy (Lecturer of anesthesia and critical care, Cairo University) — Principal investigator
First posted
Jul 24, 2025
Start date
Jul 13, 2025
Primary completion
Mar 20, 2026
Completion
Mar 20, 2026
Last update
Mar 25, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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