An observational study in VITELLIFORM LESIONS, sponsored by Federico II University. Completed at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-04.
Sponsored by Federico II University · Observational
Vitelliform lesions (VLs) are subretinal accumulations of yellowish material on fundoscopy that correspond to hyperautofluorescent material on fundus autofluorescence (FAF) and hyperreflective subretinal material on structural optical coherence tomography (OCT).
VLs are characterised by dynamic changes with progressive resorption of material and are associated with the appearance of visual symptoms, such as reduced visual acuity. The appearance of symptoms and changes in the characteristics of the VLs on retinal imaging are the basis of a sophisticated differential diagnosis, especially to distinguish a neovascular from a non-vascular sub-type.
To date, additional retinal imaging techniques can be helpful in performing differential diagnosis in unclear cases. Radiomics is a quantitative approach to medical imaging that can extract many features to improve medical diagnosis and assess response to treatment.
The aim of this study is to evaluate the performance of radiomics in the diagnosis of dynamic changes in VLs.
35 studies on the registry are indexed under Ornithine Carbamoyltransferase Deficiency Disease; 11 are open to participants now.
This study's enrollment of 50 is below the median of 66 across 20 observational studies indexed under Ornithine Carbamoyltransferase Deficiency Disease.
Browse Ornithine Carbamoyltransferase Deficiency Disease studies →Federico II University is the lead sponsor of 356 studies on the registry; 60 are open to participants now.
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Study group included all patients, over 18 years old, with a diagnosis of aVLs, evaluated from march 2022 to january 2025.
Exclusion Criteria:
The study population includes patients diagnosed with acquired vitelliforms lesions (aVLs), defined by hyperautofluorescent material on fundus autofluorescence (FAF) and hyperreflective subretinal material on structural optical coherence tomography (OCT).
Features analysis of aVLs OCT
extraction and analysis of radiomic features from OCT images to characterize empty optical spaces and distinguish empty space in dynamic changes of aVLs from the presence of fluid in case of aVLs complicated by neovascularisation
Time frame: Baseline
Plan to share: No
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This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Federico II University