An interventional study of the test group were placed in an Argon plasma reactor in Missing Tooth/Teeth, sponsored by Universita degli Studi di Genova. Not yet recruiting. Per ClinicalTrials.gov, last updated 2025-07-16.
Sponsored by Universita degli Studi di Genova · Not applicable, Interventional, and Treatment
The aim of this "in vivo" controlled trial is to assess soft tissue cell adhesion to titanium abutments subjected to different cleaning procedures - no treatment (as they come from the industry), and cleaning by plasma- at an early healing time.
In fact, the primary aim is Quantity and Quality of soft tissue adhesion at the microscopic level (e.g Fibronectin, Integrin-actin).
The secondary Aim - Clinical parameters and outcomes - BOP, PPD, MBL (Marginal Bone Level to check influence of plasmapp-treated abutments).
The null hypothesis of the study was that the cleaning procedure applied to implant abutments has no effect on soft tissue cell adhesion and MBL at an early healing time.
Exclusion Criteria:
The control group received MUA without plasma treatment.
.The MUA allocated to the test group will be placed in a plasma reactor (Plasmapp, South Korea) for decontamination and activation of the surface. In order to restrict any post-treatment contamination; abutments will be inserted immediately after the end of the plasma process.
Device: the test group were placed in an Argon plasma reactor
the test group were placed in an Argon plasma reactor
connective tissue coverage
• Coverage was defined as the extent to which the abutment surface was occupied by adherent cells. It reflects the spatial distribution of cells across the surface, providing a measure of surface colonization. Coverage was independently scored on a scale from 1 to 10 by two blinded operators who were unaware of the sample group assignments (i.e., activated vs control). The individual scores were subsequently averaged to obtain a representative value for each parameter per sample.
Time frame: 3 months post-op
Connective tissue density
• Density was defined as the degree of cellular accumulation in the regions where cells were present. This parameter reflects the local compactness of cells, irrespective of how widely they are spread across the surface. Density was independently scored on a scale from 1 to 10 by two blinded operators who were unaware of the sample group assignments (i.e., activated vs control). The individual scores were subsequently averaged to obtain a representative value for each parameter per sample.
Time frame: 3 months post-op
Mean bon loss
MBL will be measured at 1-year follow up using orthopanoramic or endo-oral Xray.
Time frame: 1 year post-op
No study locations are listed for this record.
Plan to share: Undecided
This study is not yet recruiting, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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Universita degli Studi di Genova