An interventional study of Dexmedetomidine and Bupivacaine in Knee Surgeries, sponsored by Cairo University. Completed at 1 site in Egypt. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-10.
Sponsored by Cairo University · Not applicable, Interventional, and Prevention
Dexmedetomidine used as an Additive for Ipack Block in Knee Surgery
Many types of analgesia used but multimodal analgesia showed best results The interspace between the popliteal artery and capsule of the posterior knee (IPACK) block aims to blockade of sciatic nerve terminal branches for analgesia without motor affection
. (IPACK) block is a motor power sparing procedure that involves injecting local anesthetic into the space between the popliteal artery and the posterior capsule of the knee in order to treat posterior knee pain
Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
IPACK block with 20ml bupivacaine 0.25% alone. .
Drug: Bupivacaine
IPACK block with 20 ml of bupivacaine 0.25% with dexmedetomidine 100 μg as adjuvant.
Drug: Dexmedetomidine
dexmedetomidine 100 μg as adjuvant to IPACK block with 20 ml of bupivacaine 0.25%.
20 ml of bupivacaine 0.25%.
Visual Analog Scale at rest score during first postoperative 48 hours
Visual Analog Scale at rest during first postoperative 48 hours a line 10centimeters long from zero to10 where 10 is the worst pain ever
Time frame: 48 postoperative hours
Visual Analog Scale at rest and during movement at 30 minuts, 2, 8, 16, 24, 36, and 48 hours
Visual Analog Scale at rest during 48 postoperative hour a line 10centimeters long from zero to10 where 10 is the worst pain ever
Time frame: 48 postoperative hours
Duration of the block
Duration of the block
Time frame: 48 hours
Heart Rate
Heart Rate
Time frame: 48 hours
Mean Arterial Pressure
Mean Arterial Pressure
Time frame: 48 hours
Block performance time in minutes
Block performance time in minutes
Time frame: preoperative
Incidence of adverse effects
Incidence of adverse effects
Time frame: 2 hours inPACU
Plan to share: No
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Cairo University