An observational study in Chronic Kidney Disease, Heart Failure With Preserved Ejection Fraction (HFPEF) and Obesity (Disorder), sponsored by University of Mississippi Medical Center. Recruiting at 1 site in United States. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-07-04.
Sponsored by University of Mississippi Medical Center · Observational
This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.
3,144 studies on the registry are indexed under Renal Insufficiency, Chronic; 704 are open to participants now.
This study's planned enrollment of 60 is below the median of 200 across 867 observational studies indexed under Renal Insufficiency, Chronic.
Browse Renal Insufficiency, Chronic studies →University of Mississippi Medical Center is the lead sponsor of 125 studies on the registry; 19 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 4 (57%) have results posted.
Counted across the registry records on this site, refreshed daily.
Community-dwelling ambulatory participants who have HFpEF and obesity. We will compare with health participants and participants with obesity but without HFpEF.
Criteria for Cohort 1: Healthy Participants
Inclusion Criteria:
Exclusion Criteria:
Criteria for Cohort 2: Obese Participants without HFpEF
Inclusion Criteria:
Exclusion Criteria:
Criteria for Cohort 3: HFpEF and Obese Participants
Inclusion Criteria:
Exclusion Criteria:
Other: High protein and sodium meal
Other: High protein and sodium meal
Other: High protein and sodium meal
Meal with 1g/kg protein content and 3900mg sodium
Change in measured GFR
Time frame: 5 hours
Change in urine sodium excretion
Time frame: 5 hours
Plan to share: No
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University of Mississippi Medical Center