ClinicalTrials.gg
RecruitingNCT07045870Updated Jul 10, 2025

Methods of Post Operative Analgesia in Patients Undergoing Thyroidectomy

An interventional study of group L : will receive lidocaine and group k : will receive Ketamine in Thyroid Disorder, sponsored by Sohag University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-07-10.

Sponsored by Sohag University · Not applicable, Interventional, and Other

From the registry’s dates

  • Primary completion was expected by Dec 2025, 10 months ago, but the record still lists the study as recruiting.
  • Started Jun 2025; still recruiting 1 year 4 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
18 Years to 75 Years
Sex
All
01

Study summary

this study aims to compare between effects of lidocaine and ketamine infusion on postoperative analgesia in patients undergoing thyroidectomy.

02

Conditions studied

  • Thyroid Disorder

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03

In context

Thyroid Diseases

365 studies on the registry are indexed under Thyroid Diseases; 80 are open to participants now.

This study's planned enrollment of 60 is below the median of 88 across 198 interventional studies indexed under Thyroid Diseases.

Browse Thyroid Diseases studies →

Lead sponsor

Sohag University is the lead sponsor of 1,230 studies on the registry; 636 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • age from 18 to 75 years old
  • both sexes
  • scheduled for thyroidectomy

Exclusion criteria

Exclusion Criteria:

  • toxic goiter
  • () exceeding 30 kg / m2
  • un controlled hypertension
  • sever liver or kidney disorders
  • allergy to study drugs
  • hyperthyroidism
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
60 participants (estimated)

Study arms

  • Active comparator
    group L : will receive lidocaine

    lidocaine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

    Drug: group L : will receive lidocaine

  • Active comparator
    group k : will receive ketamine

    Ketamine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

    Drug: group k : will receive Ketamine

  • Placebo comparator
    group c: will receive .9% saline

    .9% saline will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy

    Drug: group c: will recieve .9% saline

Interventions

  • Druggroup L : will receive lidocaine

    group L : will receive 1.5 mg/kg bolus of iv lidocaine 10 minutes before anaesthesia induction then continuous iv infusion rate 1.5 mg / kg / h

  • Druggroup k : will receive Ketamine

    patients will receive .25 mg / kg bolus of iv ketamine 10 minutes before anaesthesia induction then continuous iv infusion of ketamine at .25 mg /kg /h

  • Druggroup c: will recieve .9% saline

    group c will be injected with equivalent volumes and rates of .9% saline using the same application scheme as the lidocaine and ketamine as a control group

06

What researchers measure

Primary outcomes

  1. the effect of perioperative intravenous lidocaine and ketamine infusion for postoperative analgesia in patients undergoing thyroidectomy

    postoperative pain by Numerical Rating Scale (NRS) Zero means no pain and ten means worst pain

    Time frame: 24 hours posftoperative

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Ludwig B, Ludwig M, Dziekiewicz A, Mikula A, Cisek J, Biernat S, Kaliszewski K. Modern Surgical Techniques of Thyroidectomy and Advances in the Prevention and Treatment of Perioperative Complications. Cancers (Basel). 2023 May 26;15(11):2931. doi: 10.3390/cancers15112931. PubMed 37296896 ↗
  • Javidi S, Sadrizadeh S, Sadrizadeh A, Bonakdaran S, Jarahi L. Postoperative complications and long-term outcomes after total and subtotal thyroidectomy: a retrospective study. Sci Rep. 2025 Jan 29;15(1):3705. doi: 10.1038/s41598-024-79860-8. PubMed 39881145 ↗
  • Jain SN, Lamture Y, Krishna M. Enhanced Recovery After Surgery: Exploring the Advances and Strategies. Cureus. 2023 Oct 17;15(10):e47237. doi: 10.7759/cureus.47237. eCollection 2023 Oct. PubMed 38022245 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 10, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07045870
Lead sponsor
Sohag University
Responsible party
Mario Nashaat (Resident, Anasethesia, Surgical Icu, Pain management Faculty of Medicine, Sohag University, Sohag University) — Principal investigator
First posted
Jul 1, 2025
Start date
Jun 11, 2025
Primary completion
Dec 15, 2025 (estimated)
Completion
Dec 15, 2025 (estimated)
Last update
Jul 10, 2025

Study contacts

Mario N Ishak, Resident
Contact
marionashaat63@gmail.com
01210609798
Abdel Rahman H Abdel Rahman, Professor
Contact
01120320258

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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