An interventional study of Acute exercise and Cold pressor test in Healthy, sponsored by University of Massachusetts, Boston. Active, not recruiting at 1 site in United States. Open to participants aged 55 Years to 79 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-15.
Sponsored by University of Massachusetts, Boston · Not applicable, Interventional, and Basic science
The goal of this preliminary study is to learn if healthy older African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are:
During one visit in the research lab, participants will:
Completing this preliminary study will help researchers to understand more about why many AA adults have heart and kidney problems, so future research can study ways to reduce the number of AA adults who have these health issues.
Racial disparities exist in the development of high blood pressure and heart and kidney disease. Over the last 25 years, African American (AA) adults have had the greatest prevalence of high blood pressure compared to any other racial identity group in the United States. In 2015, \~100,000 AA adults died from heart disease, accounting for one-third of all deaths in this population. AA adults also have a 2-3-times higher lifetime risk for developing end-stage kidney disease compared to White (W) adults. Further, advanced age is one of the most significant risk factors for developing high blood pressure, heart disease, and kidney disease. In 2013-2014, \~29% of deaths of adults aged 65 years or older were caused by heart disease, the leading cause of death in this population.
Elevated sympathetic nervous system activity is associated with increased incidence of heart and kidney disease. Physical activity, such as exercise, acutely increases sympathetic nervous system activity, notably directed towards the kidneys, resulting in reflex narrowing of small blood vessels inside the kidneys. This response reduces blood flow to the kidneys to deliver greater blood flow to the active skeletal muscles. Most of the research studies in this area have involved participant groups who were wholly or predominantly of W racial identity, with smaller proportions of individuals of other racial identities. This underrepresentation of non-W participants, including AA adults, has occurred despite the known health disparities such as the greater incidence of high blood pressure and heart disease and kidney disease experienced by these populations.
A larger decrease in kidney blood flow during exercise has been observed in patients with heart failure and peripheral arterial disease compared to healthy adults. However, it is not known whether the decrease in kidney blood flow during exercise is larger in healthy older AA adults compared to other racial identity groups. Given the greater level of chronic psychological stress often experienced by AA adults due to systemic racism and social and environmental factors, the associated cumulative negative impact on cardiovascular health could underlie a physiological difference observed between AA and W adults. Therefore, it is hypothesized that healthy older AA adults will exhibit a larger decrease in kidney blood flow during exercise compared to W adults. This greater response in older AA adults could be a significant factor contributing to the higher rates of heart and kidney disease in this population given the negative effect that this larger response could have over time, highlighting the clinical significance of this area.
The goal of this project is to collect preliminary data regarding the kidney blood flow response to exercise in healthy older AA compared to W adults. This will be achieved through the innovative use of Doppler ultrasound to noninvasively measure kidney blood flow in real time during cycling exercise in 6 healthy older AA adults and 6 healthy older W adults. The preliminary data collected in this project will be used to strengthen future proposals to secure external funding to complete this project on a larger scale. Findings from a larger-scale project will have important implications for developing preventative strategies to reduce the elevated risk of developing heart and kidney disease in the AA population.
9,798 studies on the registry are indexed under Motor Activity; 1,910 are open to participants now.
This study's planned enrollment of 12 is below the median of 60 across 8,388 interventional studies indexed under Motor Activity.
Browse Motor Activity studies →University of Massachusetts, Boston is the lead sponsor of 23 studies on the registry; 3 are open to participants now.
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Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
African American adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded.
Other: Acute exercise · Other: Cold pressor test · Other: Mental stress test
White adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded.
Other: Acute exercise · Other: Cold pressor test · Other: Mental stress test
Participants will lie in a semi-supine position with their feet attached to the pedals of a custom-arranged cycle ergometer. Participants' 40% heart rate reserve will be calculated, giving the target value to achieve during exercise based on appropriate resistance applied on the cycle ergometer, corresponding to a moderate exercise intensity. After a 5-minute resting baseline, participants will perform dynamic cycling exercise at steady state for up to 20 minutes. They will then stop exercising, and there will be a 5-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived exertion will be taken from participants during the last 30 seconds of steady-state cycling exercise.
Participants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will have their hand immersed in ice water for 2 minutes. This cold pressor test represents the non-exercise, physical sympathetic stressor. Participants' hand will then be removed from the ice water, followed by a 3-minute recovery period. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. Ratings of hand pain and cold perception will be taken from participants during the last 30 seconds of the cold pressor test.
Participants will lie in a semi-supine position, and after a 3-minute resting baseline, participants will perform a mental arithmetic task for 5 minutes. This mental stress test represents the non-exercise, psychological sympathetic stressor. Participants will be instructed to subtract a given number from a randomly selected three-digit number and verbally state their answer and continue to do so for the duration of the test. Participants will be instructed to state their answers as quickly and accurately as possible. Participants will then stop the arithmetic task, and a 3-minute recovery period will follow. Beat-to-beat renal blood flow velocity (Doppler ultrasound), mean arterial blood pressure (finger photoplethysmographic cuff), and heart rate (electrocardiogram) will be recorded throughout. A rating of perceived stress will be taken from participants during the last 30 seconds of the mental stress test.
Change in renal vascular resistance during acute exercise
For the acute exercise intervention, the percent change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in renal vascular resistance during cold pressor test
For the cold pressor test intervention, the percent change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in renal vascular resistance during mental stress test
For the mental stress test intervention, the percent change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in renal blood flow velocity during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in mean arterial blood pressure during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in systolic blood pressure during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in diastolic blood pressure during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in heart rate during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in cardiac output during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in stroke volume during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in total peripheral resistance during acute exercise
For the acute exercise intervention, the absolute change from pre-acute exercise to during steady-state exercise will be assessed.
Time frame: Pre-acute exercise and during 5 minutes of steady-state exercise
Change in renal blood flow velocity during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in mean arterial blood pressure during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in systolic blood pressure during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in diastolic blood pressure during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in heart rate during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in cardiac output during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in stroke volume during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in total peripheral resistance during cold pressor test
For the cold pressor test intervention, the absolute change from pre-cold pressor test to 30-second intervals during the cold pressor test will be assessed.
Time frame: Pre-cold pressor test to after 30, 60, 90, and 120 seconds of cold pressor test
Change in renal blood flow velocity during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in mean arterial blood pressure during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in systolic blood pressure during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in diastolic blood pressure during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in heart rate during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in cardiac output during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in stroke volume during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Change in total peripheral resistance during mental stress test
For the mental stress test intervention, the absolute change from pre-mental stress test to 1-minute intervals during the mental stress test will be assessed.
Time frame: Pre-mental stress test to after 1, 2, 3, 4, and 5 minutes of mental stress test
Rating of perceived exertion during acute exercise
For the acute exercise intervention, the rating will be taken during the last 30 seconds of steady-state exercise. The Borg Scale of Perceived Exertion will be used, with which a rating from 6 to 20 will be taken, with 6 representing no exertion and 20 representing maximal exertion.
Time frame: During last 30 seconds of steady-state exercise
Rating of hand pain during cold pressor test
For the cold pressor test intervention, the rating will be taken during the last 30 seconds of the cold pressor test. A scale from 0 to 10 will be used to take the rating, with 0 representing no pain and 10 representing the worst possible pain.
Time frame: During last 30 seconds of cold pressor test
Rating of cold perception during cold pressor test
For the cold pressor test intervention, the rating will be taken during the last 30 seconds of the cold pressor test. A scale from 0 to -11 will be used to take the rating, with 0 representing no perceived cold and -11 representing unbearable cold.
Time frame: During last 30 seconds of cold pressor test
Rating of perceived stress during mental stress test
For the mental stress test intervention, the rating will be taken during the last 30 seconds of the mental stress test. A scale from 0 to 4 will be used to take the rating, with 0 representing no perceived stress and 4 representing extremely stressful.
Time frame: During last 30 seconds of mental stress test
Plan to share: No
No publications or documents are linked to this record.
Started Dec 2024 (actual). Primary completion is estimated for Dec 2026, 24 months after the start.
Of 5,147 non-industry interventional studies with no phase under Motor Activity, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 7 and three quarters within 36. This study's planned 24 months is above that.
Counting every sponsor, half of 5,207 studies reached it within 17 months; a quarter within 7 and three quarters within 36.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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University of Massachusetts, Boston