A Master Protocol of Multiple Interventions for the Treatment of Adults With Moderate-to-Severe Atopic Dermatitis.

• Present with a diagnosis of atopic dermatitis (AD) at least 12 months prior to screening

  • Eczema Area and Severity Index (EASI) score ≥12
  • Validated Investigator Global Assessment AD (vIGA-AD) score ≥3
  • ≥10% of BSA involvement (per EASI BSA)
• Are candidates for systemic therapy, and have a history, documented by a physician and/or the investigator, of inadequate response to existing topical medications within 6 months preceding screening.

Exclusion Criteria:

• Have a history of eczema herpeticum:

  • any episode within 12 months prior to screening, or
  • 2 or more episodes during lifetime
• Are currently experiencing or have a history of concomitant skin conditions other than AD, for example, psoriasis or cutaneous lupus, that, in the opinion of the investigator, would interfere with evaluations of the effect of study intervention on AD.
• Are currently experiencing or have a history of erythrodermic, refractory, or unstable skin disease which requires frequent hospitalizations or IV treatment and, in the opinion of the investigator, could interfere with study participation
• Are currently experiencing a skin infection that requires treatment with, or is currently being treated with, topical or systemic antibiotics.

Note: Participants who fail screening due to this criterion should not be rescreened until at least 4 weeks after screen failure and at least 2 weeks after resolution of the infection.