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Not yet recruitingNCT07016828Updated Jun 12, 2025

Guided Pterygoid Implant

An interventional study of guided surgery technique and Free hand technique in Atrophy of the Posterior Maxilla, sponsored by Fayoum University. Not yet recruiting at 1 site in Egypt. Open to participants aged 21 Years to 75 Years. Per ClinicalTrials.gov, last updated 2025-06-12.

Sponsored by Fayoum University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Randomized
Ages
21 Years to 75 Years
Sex
All
01

Study summary

Introduction \& Background Alveolar ridge resorption after tooth extraction leads to significant bone loss, complicating prosthetic rehabilitation. Traditional bone grafting methods, though effective, involve long healing times and risks. Pterygoid implants offer a graft-free alternative by engaging dense bone structures like the pterygoid process. However, their placement is technically challenging due to limited visibility and proximity to critical structures. Computer-guided surgery may improve accuracy and reduce complications compared to freehand techniques.

Research Question Does computer-guided surgery enhance the accuracy of pterygoid implant placement in atrophic maxillae compared to freehand techniques? Aim To compare the accuracy of computer-generated 3D surgical guides versus freehand placement of pterygoid implants.

Hypothesis

  • H0: No difference in accuracy between techniques.
  • Hₐ: there is difference between two techniques Study Design A prospective randomized controlled trial (1:1 allocation) with 12 implants (6 per group(.

Patient Selection Inclusion Criteria: Severe posterior maxillary atrophy (Cawood \& Howell V-VI), residual bone height \<4mm, age 21-75.

Exclusion Criteria: Contraindications for surgery, uncontrolled systemic diseases, or acute sinus infections.

Methods

  • Group A: Implants placed using CBCT-based 3D surgical guides.
  • Group B: Freehand placement based on anatomical landmarks.
  • Primary Outcome: Implant position accuracy (postoperative CBCT vs. virtual plan(.
  • Secondary Outcomes: Surgical time, complications, and stability. Surgical Procedure
  • Osteotomy: Angled drilling (45-60°) into the pterygoid process.
  • Implant Placement: Torque ≥30 Ncm for primary stability.
  • Postoperative Care: Antibiotics, analgesics, and follow-up CBCT at one week. Statistical Analysis Data analyzed using SPSS, with G*Power determining sample size (85% power, α = 0.05(.

Ethical Considerations Approved by institutional review boards, with informed consent and confidentiality maintained.

02

Conditions studied

  • Atrophy of the Posterior Maxilla

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Keywords

  • guided surgery
  • pterygoid implant
  • atrophic maxilla
03

Who can participate

Ages eligible
21 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Patients with severe posterior maxillary atrophy (Class V-VI Cawood \& Howell classification) requiring pterygoid implant placement.
  2. Patients with severe alveolar bone atrophy in posterior maxilla (Residual alveolar bone height \<4mm in posterior maxilla precluding conventional implant placement).
  3. Adequate interarch space ≥7mm for prosthetic rehabilitation.
  4. Presence of pneumatized maxillary sinus with insufficient bone for sinus augmentation.
  5. Patients aged 21-75 years with completed craniofacial growth.

Exclusion criteria

Exclusion Criteria:

  1. Patients with systemic conditions contra-indicating general anesthesia.
  2. Patients with conditions contraindicating implant placement (e.g.:

    radiation to the head and neck, intra-venous bisphosphonates, uncontrolled Diabetes mellitus).

  3. Patients with acute maxillary sinus infection or maxillary sinus cyst.
  4. Restricted mouth opening (less than 3cm inter-arch distance anteriorly).
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
12 participants (estimated)

Study arms

  • Active comparator
    Guided Surgery group

    Implants placed using CBCT-based 3D surgical guides.

    Device: guided surgery technique

  • Placebo comparator
    free hand technique group

    Freehand placement based on anatomical landmarks.

    Procedure: Free hand technique

Interventions

  • Deviceguided surgery technique

    * Clinical examination will be performed and preoperative CBCT will be taken for all the patients prior to the surgery to evaluate the posterior maxilla for the placement of the pterygoid implants. * Ideal pterygoid implant placement will be planned using the BlueSky Bio software (USA) which will be mostly to emerge from the third molar position and to engage the dense pillar of bone formed by the pyramidal process and pterygoid process of sphenoid bone. * surgical guide will be fabricated which will be either soft tissue without flap elevation.

  • ProcedureFree hand technique

    the surgery will be done without the use of the surgical guides depending on the anatomical landmarks.

05

What researchers measure

Primary outcomes

  1. Accuracy of implant position

    The primary outcome will be measured by comparing the position of implant in the virtual plan with that in the postoperative implant or the actual implant and this will be done by making a superimposition of the virtual plan with the postoperative CBCT then putting points on the coronal and apical parts of implants and then start to measure the following data: 1. direct linear measurements between the coronal and apical points of the virtual and actual implants (measured in millimeters) 2. angular deviations between the long axis of virtual and postoperative or actual implants.(measured in degrees) 3. indirect measurements of the coronal and apical points of virtual and actual implants to 3d planes.(measured in mm) All of this will be done for both groups.

    Time frame: the patient will make postoperative CBCT after one week of the surgery to compare it with the preoperative virtual planning done on the preoperative CBCT.

06

Study locations

1 site
  • Fayoum University
    Fayoum, 63514, Egypt
07

References and documents

Individual participant data

Plan to share: Undecided — I still have no decision until i start my research and getting approvals from the patients to protect their right.

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07016828
Lead sponsor
Fayoum University
Responsible party
Norhan Magdy Ahmed Yousef (dentist in medical administration at fayoum university, Fayoum University) — Principal investigator
First posted
Jun 12, 2025
Start date
Jul 30, 2025 (estimated)
Primary completion
Jun 1, 2026 (estimated)
Completion
Jun 30, 2026 (estimated)
Last update
Jun 12, 2025

Study contacts

norhan magdy yousef, BDs
Contact
nm2650@fayoum.edu.eg
+201067534200
al shimaa ahmed shaban, professor
Contact
aas16@fayoum.edu.eg
+201006047940

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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