Assessment of Drug Liking In Peri-procedural Clinical Settings

• American Society of Anesthesiologists (ASA) physical status classification of I, II or III
• Candidates who are expected to receive fentanyl up to 3 mcg/kg IBW for their scheduled for surgery or procedure

Exclusion Criteria:

• Craniofacial abnormalities
• Known or suspected difficult intubation or mask ventilation
• Known or suspected need for rapid sequence induction and intubation
• Allergies or hypersensitivities to droperidol or fentanyl
• Clinically significant pulmonary disease, such as chronic obstructive lung disease requiring long-term oxygen therapy, or other conditions that, in the study team's judgment, may increase the risk of severe respiratory depression with opioid administration
• History of long QT syndrome
• History of Torsades de Pointes
• History of psychosis
• History of movement disorders e.g. Parkinson's Disease
• Past chronic use of anti-psychotics
• Current use of droperidol, levodopa, lithium, clozapine, metoclopramide, benzodiazepines
• Current use of opioids
• History of opiate abuse within the last 3 years
• Known or suspected severe chronic pain condition that require use of opiates or limit daily activities
• History of pheochromocytoma
• History of concomitant prolactin-dependent tumors e.g. prolactinoma, breast cancer
• Pregnancy or nursing
• Current use of antiemetic medication (i.e., 5HT or dopamine antagonists)
• Active seizure disorder
• Active mental health disorders resulting in functional impairment
• Current use of psychostimulant medications (Adderall)
• Current use of CNS depressants (e.g., barbiturates, benzodiazepines)
• Severe renal insufficiency (Stage 4 or 5)
• Impaired cognitive function
• Regular Cannabis use (2+ times per week)
• Current history of substance abuse disorder.
• Failure to satisfy the investigator of fitness to participate for any other reason