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CompletedNCT07008313Updated Jun 6, 2025

Enhanced Recovery After Surgery Promotes the Rehabilitation of Patients With Acute Gastrointestinal Perforation in Perioperative Period

An interventional study of The enhanced recovery after surgery and Traditional treatment methods. in Acute Gastrointestinal Perforation and Enhanced Recovery After Surgery, sponsored by Hebei Medical University. Completed at 1 site in China. Open to participants aged 14 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-06-06.

Sponsored by Hebei Medical University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 6 years 7 months after the study started (first participant enrolled Oct 2018, registered May 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
362
Allocation
Randomized
Ages
14 Years to 80 Years
Sex
All
01

Study summary

The enhanced recovery after surgery(ERAS) has been gradually extended from its initial colorectal surgery to almost all surgical fields. However, there are few reports about the application value of ERAS in emergency surgery. The goal of this clinical trial is to evaluate the value of ERAS in the perioperative period of acute gastrointestinal perforation. All the patients will be treated by emergency operation. The changes of CRP, PA, PCT in Plasma 1 hour before operation and 1,3,7 days after operation, the operation time, the amount of bleeding during operation, the recovery time of intestinal function and the time of the first meal after operation,the incidence of postoperative complications, the degree of postoperative pain, the time of first out-of-bed activity, fatigue and mental status, quality of life, the length and the cost of hospital stay will be monitored and recorded.

02

Conditions studied

  • Acute Gastrointestinal Perforation
  • Enhanced Recovery After Surgery

Keywords

  • acute gastrointestinal perforation
  • enhanced recovery after surgery
  • perioperative period
03

In context

Lead sponsor

Hebei Medical University is the lead sponsor of 42 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
14 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age≥14years old and ≤80 years old
  • The initial diagnosis is acute gastrointestinal perforation

Exclusion criteria

Exclusion Criteria:

  • Patients with unconsciousness,or patients with past psychiatric history
  • Patients with shock and/or severe organ failure
  • Patients who are pregnant
  • Patients with severe spinal deformity who are unable to receive epidural anesthesia
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
362 participants (actual)

Study arms

  • Experimental
    the enhanced recovery after surgery (ERAS) group

    Patients were rehabilitated using the ERAS concept.

    Behavioral: The enhanced recovery after surgery

  • Placebo comparator
    the conventional surgical treatment (CST) group

    Traditional treatment methods.

    Behavioral: Traditional treatment methods.

Interventions

  • BehavioralThe enhanced recovery after surgery

    Enhanced recovery after surgery (ERAS) refers to a series of optimal management measures which are proved to be effective by evidence-based medical evidence in order to reduce patients' psychological and physiological traumatic stress reaction

  • BehavioralTraditional treatment methods.

    Traditional treatment methods.

06

What researchers measure

Primary outcomes

  1. change of the c-reactive protein in plasma

    Time frame: 1, 3, and 7 days after surgery

  2. change of the prealbumin in plasma

    Time frame: 1, 3, and 7 days after surgery

  3. change of the procalcitonin in plasma

    Time frame: 1, 3, and 7 days after surgery

07

Study locations

1 site
  • the Second Hospital of Hebei Medical University
    Shijiazhuang, Hebei, China
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Oct 2018 to primary completion in Jan 2023, 51 months.

How these figures are worked out, and which studies are left out of them.

Registered
May 29, 2025
First posted
Jun 6, 2025
StartActual
Oct 1, 2018
Primary completionActual
Jan 1, 2023
CompletionActual
Jan 31, 2023
Last update
Jun 6, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 6, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07008313
Lead sponsor
Hebei Medical University
Responsible party
Chunjie Liu (Professor, Hebei Medical University) — Principal investigator
First posted
Jun 6, 2025
Start date
Oct 1, 2018
Primary completion
Jan 1, 2023
Completion
Jan 31, 2023
Last update
Jun 6, 2025

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.

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