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Not yet recruitingNCT06980467Updated May 20, 2025

Evaluation of AI-Generated Clinical Advice by Physicians

An interventional study of Large Language Model in Artificial Intelligence (AI), sponsored by Tsinghua University. Not yet recruiting at 2 sites in China. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-05-20.

Sponsored by Tsinghua University · Not applicable, Interventional, and Other

From the registry’s dates

  • Primary completion was expected by May 2025, 1 year 4 months ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
8
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

This study examines how artificial intelligence systems interact with medical professionals. Researchers will compare physician responses to different AI-generated outputs in simulative medical scenarios.

02

Conditions studied

  • Artificial Intelligence (AI)
03

In context

Lead sponsor

Tsinghua University is the lead sponsor of 24 studies on the registry; 15 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Age ≥ 18 years old;
  • Licensed physician or medical professional qualified to perform clinical evaluations;
  • Willing to sign informed consent and commit time to participate in the study.

Exclusion criteria

Exclusion Criteria:

  • Unable to dedicate sufficient time to complete the study tasks;
  • Unable or unwilling to understand and follow study instructions.
05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Participant)
Enrollment
8 participants (estimated)

Study arms

  • No intervention
    control group

    Participants evaluate clinical recommendations generated by Language Model A (LLM-A), with subsequent assessments of communication style characteristics using rating scales.

  • Experimental
    intervention group

    Participants evaluate clinical recommendations generated by Language Model B (LLM-B), followed by evaluations of communication style characteristics through metric instruments.

    Other: Large Language Model

Interventions

  • OtherLarge Language Model

    An artificial intelligence system generating clinical recommendations using prompts, designed to simulate clinical advisory outputs. The protocol focuses on structured medical language generation.

06

What researchers measure

Primary outcomes

  1. Physician Response to AI-Generated Medical Content

    Participants will rate their level of agreement with AI-generated clinical suggestions presented in simulated medical scenarios. Responses will be recorded using a standardized rating scale (range 1-5, where higher scores indicate better agreement).

    Time frame: Through study completion, an average of 1 week

Secondary outcomes

  1. Physician Perception of Communication Quality in AI-Generated Content

    Participants will assess the communication style of AI-generated content, focusing on factors such as empathy. Ratings will be collected using a standardized 5-point scale (range 1-5, where higher scores reflect higher perceived quality).

    Time frame: Through study completion, an average of 1 week

07

Study locations

2 sites
  • Tsinghua University
    Beijing, Beijing 100084, China
  • Shanghai Health and Medical Center
    Wu Xi, Jiang Su 214065, China
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 20, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06980467
Lead sponsor
Tsinghua University
Responsible party
Tien Yin Wong (Vice-Provost and Senior Vice-Chancellor, Tsinghua University) — Principal investigator
First posted
May 20, 2025
Start date
May 15, 2025 (estimated)
Primary completion
May 22, 2025 (estimated)
Completion
May 23, 2025 (estimated)
Last update
May 20, 2025

Study contacts

Yixiao Jin
Contact
jin-yx24@mails.tsinghua.edu.cn
+86 17721026692

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in May 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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