CClinicalTrials.gg
Active, not recruitingNCT06980324Updated May 20, 2025

Neuromuscular Inhibition Technique on Iliotibial Band Friction Syndrome

An interventional study of integrated neuromuscular inhibition technique and conventional physical therapy treatment in Iliotibial Band Syndrome, sponsored by Cairo University. Active, not recruiting at 1 site in Egypt. Open to participants aged 30 Years to 50 Years. Per ClinicalTrials.gov, last updated 2025-05-20.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by May 2025, 1 year 5 months ago, but the record still lists the study as active, not recruiting.
  • Registered 1 year after the study started (first participant enrolled Mar 2024, registered Mar 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
30 Years to 50 Years
Sex
All
01

Study summary

The goal of this clinical trial is to find the effect of integrated neuromuscular inhibition technique for iliotibial band in iliotibial band friction syndrome on pain intensity level, pressure pain threshold, knee range of motion, knee function and knee angle . The main questions it aims to answer are:

  • Is there an effect of integrated neuromuscular inhibition technique for iliotibial band on pain intensity level in iliotibial band friction syndrome?
  • Is there an effect of integrated neuromuscular inhibition technique for iliotibial band on pressure pain threshold in iliotibial band friction syndrome?
  • Is there an effect of integrated neuromuscular inhibition technique for iliotibial band on knee range of motion in iliotibial band friction syndrome?
  • Is there an effect of integrated neuromuscular inhibition technique for iliotibial band on knee function in iliotibial friction syndrome? Is there an effect of integrated neuromuscular inhibition technique for iliotibial band on knee angle in iliotibial band friction syndrome?

Researchers will compare integrated neuromuscular inhibition technique to conventional physiotherapy to see if integrated neuromuscular inhibition technique works to treat iliotibial band syndrome.

Participants will:

  • Take sessions for 2 weeks
  • Visit the department 3 times per week
02

Conditions studied

  • Iliotibial Band Syndrome

Keywords

  • integrated neuromuscular inhibition technique
  • iliotibial band friction syndrome
  • muscle energy technique
  • ischemic compression
  • positional release
03

In context

Syndrome

9,217 studies on the registry are indexed under Syndrome; 1,031 are open to participants now.

This study's planned enrollment of 40 is below the median of 50 across 6,515 interventional studies indexed under Syndrome.

Browse Syndrome studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Body mass index from 25-30 kg/m2
  • Both males and females will be included their age from 30-50.
  • The subjects that will be included in the study will be referred from orthopeadic physician with iliotibial band friction syndrome with these signs and symptoms
  • local tenderness of the lateral knee inferior to the epicondyle and superior to the joint line
  • Pain with ITBS can be reported anywhere along the iliotibial (IT) band from the lateral thigh to the lateral femoral condyle and Gerdy's tubercle.
  • Pain is most intense at approximately 30 degrees of knee.
  • A sharp, burning pain when the practitioner presses on the lateral epicondyle during knee flexion and extension associated with one of these cases:
  • Tibiofermoral knee pain.
  • Patellofemoral knee pain.
  • osteoarthritis with medial knee joint pain
  • Lateral patellar pressure syndrome.
  • Medial meniscus degeneration.
  • Excessive lateral pressure syndrome

Exclusion criteria

Exclusion Criteria:

  • Traumatic injury to the knee joint within 6 months.
  • Surgical procedure on the affected knee within the last 12 months.
  • Meniscus injury
  • knee ligaments injury
  • Malignancies, tumors or infections associated with the knee joint.
  • Impaired thermal sensation over the knee.
  • Subject with psychiatric disorder.
  • Peripheral vascular disease.
  • Severe joint deformity.
  • Current back or ankle pain.
  • Rheumatoid arthritis.
  • Lower extremity fracture.
  • Neurological defecit or movement disorder.
  • Athletes.
  • Menopause
  • Pregnancy
  • Auto immune disease
  • Chronic disease (Diabetes mellitus and Hypertension)
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
40 participants (estimated)

Study arms

  • Experimental
    control group

    Other: conventional physical therapy treatment

  • Experimental
    Interventional group

    Other: integrated neuromuscular inhibition technique

Interventions

  • Otherintegrated neuromuscular inhibition technique

    integrated neuromuscular inhibition technique consists of: * ischemic compression * Positional release * Muscle energy technique

  • Otherconventional physical therapy treatment

    Conventional physical therapy treatment: * Ultrasound * Hotpacks * Iliotibial band stretching * Static quadriceps and hamstring exercises

06

What researchers measure

Primary outcomes

  1. Pain intensity

    The Visual Analogue Scale (VAS) was used to evaluate pain severity. It is a self-reported pain measurement scale, consisting of a horizontal or vertical line, usually 10 cm long. The extremes of the line are labeled as no pain and worst pain. Each subject was asked to mark the point on the line that exactly corresponded to his/her pain

    Time frame: after 2 weeks

  2. lower extremity function

    Lower extremity functional scale (LEFS): LEFS is a questionnaire containing 20 items assessing the lower extremity function based on the intensity of the related activities' performance. This scoring system is designed based on the five-score Likert scale ranging from zero as the worst condition to four as without bothersome. This scale scores from zero to eighty and the higher score represent a better condition. LEFS-Arabic version will be used to quantify activity limitation in Arabic-speaking individuals with lower extremity musculoskeletal disorders

    Time frame: after 2 weeks

  3. Knee range of motion

    Digital goniometer: A goniometer is a device that measures an angle or permits the rotation of an object to a definite position .To measure knee joint ROM goniometer was lined up with the lateral side of femur with the proximal arm between trochanter major and the middle of the lateral joint space of the knee and the distal arm between the middle of the lateral joint space of the knee and the lateral malleoli

    Time frame: after 2 weeks

Secondary outcomes

  1. pressure pain threshold

    The pressure algometer was applied three times at each of the three marked points. Each application of the pressure algometer was stopped when the participant perceived a change in sensation from pressure to pain at the measurement point. Using a mechanical pressure Fischer algometer . Pressure was increased with a speed (1kg/cm2). Steady and perpendicular to the identified trigger point, subjects were instructed to say "now" when they first began to feel change of pressure to either discomfort or pain. The mean of 3 trials over each point was calculated. It is important to place the tip of the algometer precisely on the MTrP region to avoid any major difference in readings among the consecutive measurements of the same MTrP.

    Time frame: after 2 weeks

  2. knee angle

    Kinovea is one of the most commonly used applications. Kinovea is a free 2D motion analysis software for computers that can be used to measure kinematic parameters. Subjects were required to stand and relaxed lower limbs, with feet forward and shoulder-width apart. The camera was set 3 m from the subject . The vertical axis of the camera was aligned with the midpoint between the lower limbs of the participant. The image was zoomed to the closest capture, where the stickers could be clearly visible, and always set in the same position.

    Time frame: after 2 weeks

07

Study locations

1 site
  • Faculty of physical therapy, Cairo university
    Giza, Egypt
08

References and documents

Publications

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  • Zhang DH, Wu ZQ, Zuo XC, Li JW, Huang CL. Diagnosis and treatment of excessive lateral pressure syndrome of the patellofemoral joint caused by military training. Orthop Surg. 2011 Feb;3(1):35-9. doi: 10.1111/j.1757-7861.2010.00116.x. PubMed 22009978 ↗
  • Whelton H, Harrington J, Crowley E, Kelleher V, Cronin M, Perry IJ. Prevalence of overweight and obesity on the island of Ireland: results from the North South Survey of Children's Height, Weight and Body Mass Index, 2002. BMC Public Health. 2007 Jul 31;7:187. doi: 10.1186/1471-2458-7-187. PubMed 17672893 ↗
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  • Kang SY, Choung SD, Park JH, Jeon HS, Kwon OY. The relationship between length of the iliotibial band and patellar position in Asians. Knee. 2014 Dec;21(6):1135-8. doi: 10.1016/j.knee.2014.09.005. Epub 2014 Oct 12. PubMed 25311516 ↗
  • Macfarlane GJ, de Silva V, Jones GT. The relationship between body mass index across the life course and knee pain in adulthood: results from the 1958 birth cohort study. Rheumatology (Oxford). 2011 Dec;50(12):2251-6. doi: 10.1093/rheumatology/ker276. Epub 2011 Oct 8. PubMed 21984765 ↗
  • Vasilevska V, Szeimies U, Stabler A. Magnetic resonance imaging signs of iliotibial band friction in patients with isolated medial compartment osteoarthritis of the knee. Skeletal Radiol. 2009 Sep;38(9):871-5. doi: 10.1007/s00256-009-0704-z. Epub 2009 May 30. PubMed 19484234 ↗
  • Svensson M, Lind V, Lofgren Harringe M. Measurement of knee joint range of motion with a digital goniometer: A reliability study. Physiother Res Int. 2019 Apr;24(2):e1765. doi: 10.1002/pri.1765. Epub 2018 Dec 27. PubMed 30589162 ↗
  • Strauss EJ, Kim S, Calcei JG, Park D. Iliotibial band syndrome: evaluation and management. J Am Acad Orthop Surg. 2011 Dec;19(12):728-36. doi: 10.5435/00124635-201112000-00003. PubMed 22134205 ↗
  • Sorour AS, Ayoub AS, Abd El Aziz EM. Effectiveness of acupressure versus isometric exercise on pain, stiffness, and physical function in knee osteoarthritis female patients. J Adv Res. 2014 Mar;5(2):193-200. doi: 10.1016/j.jare.2013.02.003. Epub 2013 Apr 8. PubMed 25685487 ↗
  • Bassiouni H, Aly H, Zaky K, Abaza N, Bardin T. Probing The Relation Between Vitamin D Deficiency and Progression of Medial Femoro-tibial Osteoarthitis of the Knee. Curr Rheumatol Rev. 2017;13(1):65-71. doi: 10.2174/1573397112666160404124532. PubMed 27041085 ↗
  • Saadat Z, Hemmati L, Pirouzi S, Ataollahi M, Ali-Mohammadi F. Effects of Integrated Neuromuscular Inhibition Technique on pain threshold and pain intensity in patients with upper trapezius trigger points. J Bodyw Mov Ther. 2018 Oct;22(4):937-940. doi: 10.1016/j.jbmt.2018.01.002. Epub 2018 Jan 17. PubMed 30368338 ↗
  • Rupareliya JD, Donga S, Gandhi AJ. Management of Vandhyatva w.s.r. to thin endometrium through Ayurveda- A single arm open labelled pilot clinical trial. Ayu. 2021 Oct-Dec;42(4):156-163. doi: 10.4103/ayu.ayu_132_21. Epub 2023 May 17. PubMed 37347080 ↗
  • Noori SA, Rasheed A, Aiyer R, Jung B, Bansal N, Chang KV, Ottestad E, Gulati A. Therapeutic Ultrasound for Pain Management in Chronic Low Back Pain and Chronic Neck Pain: A Systematic Review. Pain Med. 2020 Nov 7;21(7):1482-1493. doi: 10.1093/pm/pny287. PubMed 30649460 ↗
  • Dobec-Meic B, Pikija S, Cvetko D, Trkulja V, Pazanin L, Kudelic N, Rotim K, Pavlicek I, Kostanjevec AR. Intracranial tumors in adult population of the Varazdin County (Croatia) 1996-2004: a population-based retrospective incidence study. J Neurooncol. 2006 Jul;78(3):303-10. doi: 10.1007/s11060-005-9100-2. Epub 2006 Apr 6. PubMed 16598428 ↗
  • Koh RG, Paul TM, Nesovic K, West D, Kumbhare D, Wilson RD. Reliability and minimal detectable difference of pressure pain thresholds in a pain-free population. Br J Pain. 2023 Jun;17(3):239-243. doi: 10.1177/20494637221147185. Epub 2022 Dec 23. PubMed 37342397 ↗
  • Kinser AM, Sands WA, Stone MH. Reliability and validity of a pressure algometer. J Strength Cond Res. 2009 Jan;23(1):312-4. doi: 10.1519/jsc.0b013e31818f051c. PubMed 19130648 ↗
  • Imamura M, Alfieri FM, Filippo TR, Battistella LR. Pressure pain thresholds in patients with chronic nonspecific low back pain. J Back Musculoskelet Rehabil. 2016 Apr 27;29(2):327-336. doi: 10.3233/BMR-150636. PubMed 26406214 ↗
  • Hutchinson LA, Lichtwark GA, Willy RW, Kelly LA. The Iliotibial Band: A Complex Structure with Versatile Functions. Sports Med. 2022 May;52(5):995-1008. doi: 10.1007/s40279-021-01634-3. Epub 2022 Jan 24. PubMed 35072941 ↗
  • Hamstra-Wright KL, Jones MW, Courtney CA, Maiguel D, Ferber R. Effects of iliotibial band syndrome on pain sensitivity and gait kinematics in female runners: A preliminary study. Clin Biomech (Bristol). 2020 Jun;76:105017. doi: 10.1016/j.clinbiomech.2020.105017. Epub 2020 Apr 30. PubMed 32388078 ↗
  • Lashien SA, Abdelnaeem AO, Gomaa EF. Effect of hip abductors training on pelvic drop and knee valgus in runners with medial tibial stress syndrome: a randomized controlled trial. J Orthop Surg Res. 2024 Oct 29;19(1):700. doi: 10.1186/s13018-024-05139-3. PubMed 39468623 ↗
  • Ferber R, Noehren B, Hamill J, Davis IS. Competitive female runners with a history of iliotibial band syndrome demonstrate atypical hip and knee kinematics. J Orthop Sports Phys Ther. 2010 Feb;40(2):52-8. doi: 10.2519/jospt.2010.3028. PubMed 20118523 ↗
  • Farrokhi S, Chen YF, Piva SR, Fitzgerald GK, Jeong JH, Kwoh CK. The Influence of Knee Pain Location on Symptoms, Functional Status, and Knee-related Quality of Life in Older Adults With Chronic Knee Pain: Data From the Osteoarthritis Initiative. Clin J Pain. 2016 Jun;32(6):463-70. doi: 10.1097/AJP.0000000000000291. PubMed 26308705 ↗
  • Farasyn A. (2007) Pressure pain algometry in patients with non-specific low back pain. Faculty of Physical Education and Physiotherapy Department of Human Physiology & Sports Medicine
  • Evans P. The postural function of the iliotibial tract. Ann R Coll Surg Engl. 1979 Jul;61(4):271-80. PubMed 475270 ↗
  • Dixit, M., Samal, S., & Ramteke, SEfficacy of Maitland Mobilization and Myofascial Trigger Point Release in Patients of Osteoarthritis of Knee. Indian Journal of Public Health Research & Development, (2020), 11(5), 705-710.
  • Dekkers JC, van Wier MF, Hendriksen IJ, Twisk JW, van Mechelen W. Accuracy of self-reported body weight, height and waist circumference in a Dutch overweight working population. BMC Med Res Methodol. 2008 Oct 28;8:69. doi: 10.1186/1471-2288-8-69. PubMed 18957077 ↗
  • Danazumi MS, Yakasai AM, Ibrahim AA, Shehu UT, Ibrahim SU. Effect of integrated neuromuscular inhibition technique compared with positional release technique in the management of piriformis syndrome. J Osteopath Med. 2021 May 31;121(8):693-703. doi: 10.1515/jom-2020-0327. PubMed 34049428 ↗
  • Crossley KM, Callaghan MJ, van Linschoten R. Patellofemoral pain. Br J Sports Med. 2016 Feb;50(4):247-50. doi: 10.1136/bjsports-2015-h3939rep. PubMed 26834209 ↗
  • Chitale N Jr, Patil DS, Phansopkar P. Integrated Neuromuscular Inhibition Technique Versus Mulligan Mobilization on Functional Disability in Subjects With Nonspecific Low Back Pain: A Comparative Study. Cureus. 2022 Oct 13;14(10):e30253. doi: 10.7759/cureus.30253. eCollection 2022 Oct. PubMed 36381847 ↗
  • Chevalier A, Van Overmeire A, Vermue H, Pringels L, Herregodts S, Victor J, Loccufier M. Effect of iliotibial band and gastrocnemius activation on knee kinematics. Knee. 2023 Jan;40:238-244. doi: 10.1016/j.knee.2022.11.025. Epub 2022 Dec 13. PubMed 36521416 ↗
  • Bose K, Kanagasuntheram R, Osman MB. Vastus medialis oblique: an anatomic and physiologic study. Orthopedics. 1980 Sep 1;3(9):880-3. doi: 10.3928/0147-7447-19800901-12. PubMed 24822568 ↗
  • Begum M.R. (2019) Validity and reliability of visual analogue scale (vas) for pain measurement. Journal of Medical Case Reports and Reviews 2.
  • Al-Najjar, H. M. M., Mohammed, A. H., & Mosaad, D. M. Effect of ice massage with integrated neuromuscular inhibition technique on pain and function in subjects with mechanical neck pain: randomized controlled trial. Bulletin of Faculty of Physical Therapy, (2020), 25, 1-7
  • Alnahdi AH, Alrashid GI, Alkhaldi HA, Aldali AZ. Cross-cultural adaptation, validity and reliability of the Arabic version of the Lower Extremity Functional Scale. Disabil Rehabil. 2016;38(9):897-904. doi: 10.3109/09638288.2015.1066452. Epub 2015 Jul 17. PubMed 26186622 ↗
  • Ali Ismail AM, Abd El-Azeim AS, El-Sayed Felaya EE. Integrated neuromuscular inhibition technique versus spray and stretch technique in neck pain patients with upper trapezius trigger points: a randomized clinical trial. J Man Manip Ther. 2024 Apr;32(2):141-149. doi: 10.1080/10669817.2023.2192899. Epub 2023 Mar 23. PubMed 36951194 ↗
  • Abaza SE. The dilemma of knee osteoarthritis and iliotibial band syndrome. MOJ Orthop Rheumatol. 2015,2(4):145-146.

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 20, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06980324
Lead sponsor
Cairo University
Responsible party
Esraa Tarek Farouk (Basic science physical therapist, Cairo University) — Principal investigator
First posted
May 20, 2025
Start date
Mar 2, 2024
Primary completion
May 2025 (estimated)
Completion
Jul 2025 (estimated)
Last update
May 20, 2025

Study contacts

AMIR MO Saleh, Professor of Physical Therapy
study chair · Cairo University
Doaa RA Elazab, Assistant professor
study director · Cairo University
Hassan HU Ahmed, Orthopedic Surgery Professor
study director · Faculty of Medicine Banha University
Esraa TA Farouk, Physical therapist
principal investigator · Cairo University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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