A Phase 4 interventional study of Eflornithine Topical and Instense pulsed light in Hirsuitism, sponsored by Khyber Teaching Hospital. Recruiting at 3 sites in Pakistan. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2025-07-03.
Sponsored by Khyber Teaching Hospital · Phase 4, Interventional, and Treatment
The study compares the effects of a cream alone and a combined effect of cream and laser for the treatment of excessive facial hairs in women .
Hirsuitism refers to excessive terminal hairs in females, following a distribution pattern typically associated with male. It is associated with either increase response of hair follicles to androgen or either increase level of circulating androgens.The treatment options available are topical creams like eflornithine and laser treatments for hair removal. This study aims to conduct the comparison of a eflornithine cream and intense pulsed light laser versus eflornithine cream alone for the treatment of excessive facial hairs.
41 studies on the registry are indexed under Hirsutism; 8 are open to participants now.
This study's planned enrollment of 122 is above the median of 43 across 26 interventional studies indexed under Hirsutism.
Browse Hirsutism studies →Khyber Teaching Hospital is the lead sponsor of 29 studies on the registry; 19 are open to participants now.
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Gender (Female) Age between 18-45 Years Women with hirsutism as mentioned in the operational definition
Exclusion Criteria:
Pregnant women Women with severe acne Women with immunodeficiency
This group is treated with combination of eflornithine cream and intense pulsed light for a period of three month.
Radiation: Instense pulsed light · Drug: Eflornithine Topical
This group is treated with eflornithine cream twice daily only for a period of three month
Drug: Eflornithine Topical
Eflornithine cream will be applied to the face of group B female patients
Also known as: Eflornithine cream
Intense pulse light will be applied to the face of patient of Group A on areas having increase hair. Patient will be called for a followup every month for next session.
Eflornithine will be given to group A patient along with intense pulsed light and results will be compared to group B who recieved only Eflornithine cream
Efficacy of treatment
Efficacy of treatment is defined as complete clearance of excessive hairs assesed on the basis of 4- level scale ranging 0 to 3 after 3 months of administration of the treatment in both groups. Clear is grade 3 Marked improvement is grade2 Improved is grade1 No improvement is grade 0
Time frame: 3 months
Plan to share: No — Because the confedentiality of the patient would be breached.
No publications or documents are linked to this record.
Start is estimated for Jul 2025; primary completion for Dec 2025, 5 months later.
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Khyber Teaching Hospital