An interventional study of cryo nerve block at T3-T8 intercostal nerves bilaterally in Lung Transplant; Pain, sponsored by University Hospital, Gasthuisberg. Recruiting at 1 site in Belgium. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-05.
Sponsored by University Hospital, Gasthuisberg · Not applicable, Interventional, and Treatment
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Among 150 studies in Pain with a site in Belgium — 24 open to participants now, 26 under way, none of them phase 3. Pain · Belgium.
Among the 150 studies in Pain with a site in Belgium, this one is the 79th largest by planned enrollment of the 115 interventional ones that give a count, is one of 6 that started in 2026, is one of 63 with no phase, reaches primary completion later than 11 of the 25 other live ones, and was the 137th registered.
10,060 studies on the registry are indexed under Pain; 1,651 are open to participants now.
Browse Pain studies →24 of the 150 studies in Pain with a site in Belgium are open now. Recruiting first, the newest first:
Erasme University Hospital · Sites in Belgium
Ages 18+
Farraj Miguel · Sites in Belgium, France
Ages 18+
Jessa Hospital · Sites in Belgium
Ages 18+
Vrije Universiteit Brussel · Sites in Belgium
Ages 18–70 · Healthy volunteers
Vrije Universiteit Brussel · Sites in Belgium
Ages 18–60 · Healthy volunteers
A study can be open while its sites in Belgium have not opened yet or have stopped. Only those recruiting at a site in Belgium →
Of the 929 Pain studies recruiting now, 384 (41%) set no upper age limit and 434 (47%) stop at 75 or younger; 146 take children under 18; 222 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
150 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 10 · Phase 2 8 · Phase 3 24 · Phase 4 13
First in 2003; this study’s year is marked. 6 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 40 is below the median of 66 across 8,497 interventional studies indexed under Pain.
Median enrollment 64 across the 115 interventional studies, 108 across the 34 observational. Of the 113 that completed or were terminated, 22 (19%) have results posted.
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44 of 150 have an industry lead sponsor. The 10 most frequent:
University Hospital, Gasthuisberg is the lead sponsor of 51 studies on the registry; 4 are open to participants now.
University Hospital, Gasthuisberg has 4 studies filed under Pain — fewer than ten, so there is no comparison to draw.
9 of the studies in Pain with a site in Belgium that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT05387473Vrije Universiteit BrusselAdded Value of Cognitive Behavioural Therapy for Insomnia in Persons With Knee Osteoarthritis | 2026-12 |
| NCT07120646Vrije Universiteit BrusselPain and Sleep Disturbances in Children Living Beyond Cancer: A Case-Control Study | 2026-12 |
| NCT06970028Universitaire Ziekenhuizen KU LeuvenSomatosensory Phenotyping of ADPKD | 2026-12 |
| NCT06767930Université Catholique de LouvainEffects of HABIT-ILE in Adults with Bilateral Cerebral Palsy | 2026-12-31 |
| NCT06959056University Hospital, GasthuisbergEvaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation | 2026-12-31 |
Add all 9 to your calendar (.ics) → With an account.
Among the 150 studies in Pain with a site in Belgium, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal of this pilot trial is to learn whether the use of cryo nerve block and its effect on sensation in the chest alters recovery after bilateral lung transplantation, and to which extent these parameters are influenced. As this study is setup as a pilot study, the main questions it aims to determine the potential impacted parameters as well as their effect sizes, of cryo-analgesia on both short and long term outcomes following bilateral lung transplantation in COPD patients in a European high volume lung transplant centre.
The efficacy parameters under evaluation will be:
Participants will:
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will undergo cryo nerve block at 6 levels of intercostal muscles, on each side from T3 to T8, 3cm lateral to the parasympathetic chain. The intervention will be performed after receptor pneumonectomy on each side.
Device: cryo nerve block at T3-T8 intercostal nerves bilaterally
Participants in the control arm will receive standard institutional pain care following bilateral lungtransplantation.
In order to obtain better analgesia at the level of the chest wall, where the chest is bilaterally opened for lung extraction and donor lung implantation, intraoperative cryo-ablation will be applied to the intercostal nerves at the bilateral intercostal spaces 3-8, 3cm lateral to the sympathetic chain, under direct visualization during surgery, as such covering 2 intercostal levels above as well as below the normal access of ICR 4 or 5. By providing analgesia to level 8, we will also cover the area of chest drains, which also tend to cause pain in the postoperative course, especially when patients start mobilizing at the ward. Each nerve bundle will be cooled to a temperature between -65 and -72 °C during 120 seconds by means of the CyroSphere v2 probe (AtriCure Inc; Mason, OH, USA) connected to the provided instrument tower (AtriCure CryoICE box) including a processor device measuring and regulating the N2O flow through the probe.
Visual Analogue pain Scale value
The highest pain score throughout the day in a participant, expressed on a Visual Analogue Scale instrument for assessing pain will be recorded. Patients will be asked specifically about thoracic/chest pain and asked to rate this pain on a Likert pain scale of 0-10, 0 being no pain and 10 being the worst pain they can imagine.
Time frame: Postoperative days 0 to 7, 14, and 21 and every month postoperative until 1 year postoperative
Lung function
Lung function evaluated by spirometry, recorded as Forced Expiratory Value at one second and Functional Vital Capacity expressed in liters and percentage of the expected.
Time frame: 1, 2, 3, 6 and 12 months postoperative
opioid consumption
use of iv or oral morphin derivatives including tramadol, as well as transdermal delivery forms, expressed in oral morphine milligram equivalents (OMME)
Time frame: postoperative days 1-7, and every monthly contact until 1 year postoperative
Length of stay (LOS) at ICU
length of stay at the intensive care unit, expressed in days
Time frame: from transplantation until actual discharge of the intensive care unit, between 2 days and 6 months postoperative
Total hospital length of stay (HLOS)
total length of hospital stay, expressed in days
Time frame: from treatment until last day in the hospital of the index admission, between 2 days and 6 months postoperative
Evaluation of Quality of life - SF12
Evaluation of quality of life by completion of standardized Quality of Life questionnaire (Short Form -12 (SF12)); 5 point likert scale; higher score equals better quality of life
Time frame: single time points at 1, 2, 3, 6 months and 1 year postoperative
Evaluation of Quality of life - EQ5D5L
Evaluation of quality of life by completion of standardized Quality of Life questionnaire (Evaluation of Quality of Life in 5 domains at 5 levels (EQ5D5L)); minimum score 5, maximum score 25; lower score equals better quality of life
Time frame: single time points at 1, 2, 3, 6 months and 1 year postoperative
Evaluation of Quality of life - Brief Pain Inventory
Evaluation of quality of life by completion of standardized Quality of Life questionnaire (Brief Pain Inventory); lower score equals better quality of life
Time frame: single time points at 1, 2, 3, 6 months and 1 year postoperative
Evaluation of Neuropathic Pain
Evaluation of pain characteristics in order to probe for neuropathic pain levels by means of the Neuropathic Pain Assessment questionnaire; 5 point likert scale, higher score is worse
Time frame: single time points at 1, 2, 3, 6 months and 1 year postoperative
Plan to share: No — Data embargo imposed by the research institution
No publications or documents are linked to this record.
Started Jan 2026 (actual). Primary completion is estimated for Dec 2026, 11 months after the start.
Of 3,734 non-industry interventional studies with no phase under Pain, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 4 and three quarters within 23. This study's planned 11 months is close to that.
Counting every sponsor, half of 3,833 studies reached it within 10 months; a quarter within 4 and three quarters within 23.
How these figures are worked out, and which studies are left out of them.
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University Hospital, Gasthuisberg