An interventional study of Partial Sleep Deprivation in Cardiovascular Health and Sleep, sponsored by Florida State University. Completed at 1 site in United States. Open to participants aged 18 Years to 39 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-06-08.
Sponsored by Florida State University · Not applicable, Interventional, and Other
The goal of this interventional study is to differentiate the effects of an acute partial sleep deprivation intervention on markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing in active vs sedentary individuals. The main aims of the project are:
Participants will be divided into two groups based on aerobic activity level - active or sedentary - and assessed for markers of cardiovascular health, cardio-autonomic function, physical and cognitive performance, as well as overall wellbeing before and after three days of normal sleep and three days of partially deprived sleep (i.e., 30% reduction in total time in bed).
Florida State University is the lead sponsor of 241 studies on the registry; 46 are open to participants now.
Of its 15 completed or terminated interventional studies of FDA-regulated products, 9 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
30% reduction in habitual time in bed
Other: Partial Sleep Deprivation
30% reduction in habitual time in bed
Also known as: Reduced Sleep
Arterial Stiffness
Carotid-femoral pulse wave velocity measured via applanation tonometry
Time frame: Following 3-days of Acute Sleep Deprivation (i.e., 30% reduction in total time in bed) as well as following 3-days of Normal Sleep (i.e., 100% habitual time in bed); performed in a randomized order
| Milestone | Active Group: Normal Sleep, Then Acute Sleep Deprivation | Active Group: Acute Sleep Deprivation, Then Normal Sleep | Sedentary Group: Normal Sleep, Then Acute Sleep Deprivation | Sedentary Group: Acute Sleep Deprivation, Then Normal Sleep |
|---|---|---|---|---|
| Started | 6 | 6 | 6 | 6 |
| Completed | 6 | 6 | 6 | 6 |
| Not completed | 0 | 0 | 0 | 0 |
| Milestone | Active Group: Normal Sleep, Then Acute Sleep Deprivation | Active Group: Acute Sleep Deprivation, Then Normal Sleep | Sedentary Group: Normal Sleep, Then Acute Sleep Deprivation | Sedentary Group: Acute Sleep Deprivation, Then Normal Sleep |
|---|---|---|---|---|
| Started | 6 | 6 | 6 | 6 |
| Completed | 6 | 6 | 6 | 6 |
| Not completed | 0 | 0 | 0 | 0 |
| Milestone | Active Group: Normal Sleep, Then Acute Sleep Deprivation | Active Group: Acute Sleep Deprivation, Then Normal Sleep | Sedentary Group: Normal Sleep, Then Acute Sleep Deprivation | Sedentary Group: Acute Sleep Deprivation, Then Normal Sleep |
|---|---|---|---|---|
| Started | 6 | 6 | 6 | 6 |
| Completed | 6 | 6 | 6 | 6 |
| Not completed | 0 | 0 | 0 | 0 |
Carotid-femoral pulse wave velocity measured via applanation tonometry
| meters per second | Active Group: Normal Sleep | Active Group: Acute Sleep Deprivation | Sedentary Group: Normal Sleep | Sedentary Group: Acute Sleep Deprivation |
|---|---|---|---|---|
| Arterial Stiffness | 5.7 ± 0.6 | 5.4 ± 0.6 | 5.5 ± 0.7 | 5.7 ± 0.5 |
Collected over from enrollment through study completion, an average of 1 month. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Active Group: Normal Sleep | 0/12 (0%) | 0/12 (0%) | 0/12 (0%) |
| Active Group: Acute Sleep Deprivation | 0/12 (0%) | 0/12 (0%) | 0/12 (0%) |
| Sedentary Group: Normal Sleep | 0/12 (0%) | 0/12 (0%) | 0/12 (0%) |
| Sedentary Group: Acute Sleep Deprivation | 0/12 (0%) | 0/12 (0%) | 0/12 (0%) |
| Age, Continuous(years) | Active Group: Normal Sleep, Then Acute Sleep Deprivation | Active Group: Acute Sleep Deprivation, Then Normal Sleep | Sedentary Group: Normal Sleep, Then Acute Sleep Deprivation | Sedentary Group: Acute Sleep Deprivation, Then Normal Sleep | Total |
|---|---|---|---|---|---|
| Mean | 23.4 ± 5.8 | 23.4 ± 5.8 | 22.2 ± 4.2 | 22.2 ± 4.2 | 22.8 ± 5.0 |
| Sex: Female, Male(Participants) | Active Group: Normal Sleep, Then Acute Sleep Deprivation | Active Group: Acute Sleep Deprivation, Then Normal Sleep | Sedentary Group: Normal Sleep, Then Acute Sleep Deprivation | Sedentary Group: Acute Sleep Deprivation, Then Normal Sleep | Total |
|---|---|---|---|---|---|
| Female | 2 | 3 | 2 | 3 | 10 |
| Male | 4 | 3 | 4 | 3 | 14 |
| Race (NIH/OMB)(Participants) | Active Group: Normal Sleep, Then Acute Sleep Deprivation | Active Group: Acute Sleep Deprivation, Then Normal Sleep | Sedentary Group: Normal Sleep, Then Acute Sleep Deprivation | Sedentary Group: Acute Sleep Deprivation, Then Normal Sleep | Total |
|---|---|---|---|---|---|
| American Indian or Alaska Native | 0 | 0 | 0 | 0 | 0 |
| Asian | 1 | 0 | 0 | 0 | 1 |
| Native Hawaiian or Other Pacific Islander | 0 | 0 | 0 | 0 | 0 |
| Black or African American | 1 | 0 | 2 | 1 | 4 |
| White | 4 | 6 | 4 | 5 | 19 |
| More than one race | 0 | 0 | 0 | 0 | 0 |
| Unknown or Not Reported | 0 | 0 | 0 | 0 | 0 |
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Florida State University