An interventional study of pulp lavage Octenidine and pulp lavage NaOCl in Pulp Exposure, Dental, sponsored by Aydin Adnan Menderes University. Active, not recruiting at 1 site in Turkey. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-27.
Sponsored by Aydin Adnan Menderes University · Not applicable, Interventional, and Treatment
In the included patients, after complete removal of caries from the entire cavity, the exposed pulp will be treated with either a 2.5% NaOCl or 0.1% Octenidine solution. Subsequently, the cavity will be restored using calcium silicate cement, glass ionomer cement, and composite resin. Postoperatively, the patient's pain level will be assessed using the Visual Analogue Scale (VAS) at 24 and 72 hours, as well as on the 7th day. Responses to pulp sensitivity tests and periapical radiographs will be evaluated at 6 months.
After obtaining a detailed pain history from the patients and conducting clinical and radiographic examinations, if a case is deemed suitable for the study, patients will be informed about the possibility of participating in this research project and the procedures involved. The risks and benefits associated with the study will be explained to the patients. Once a patient is considered a potential candidate for the study and expresses interest in participation, informed consent will be obtained.
Before the caries removal procedure, local anesthesia will be administered, and the teeth will be isolated using a rubber dam. Cavities will be prepared using a diamond bur under continuous water cooling. Caries will be completely removed from the entire cavity with the help of steel round burs and excavators, continuing until hard dentin is reached. Bleeding from the exposed pulp will be controlled by pressing a cotton pellet soaked in sterile physiological saline onto the exposure site for one minute. At this point, a researcher not involved in this study will provide the treating clinician with a glass dish containing either a 2.5% NaOCl or 0.1% Octenidine solution. A cotton pellet soaked in the test or control solution will be applied to the exposed pulp, and the cavity will be gently wiped. The cavity will be restored using calcium silicate cement, glass ionomer cement, and composite resin. Postoperatively, the patient's pain levels will be assessed using the Visual Analogue Scale (VAS) at 24 and 72 hours, as well as on the 7th day. Pulp sensitivity tests and periapical radiographs will be conducted at 6 months to evaluate the outcome.
29 studies on the registry are indexed under Dental Pulp Exposure; 5 are open to participants now.
This study's planned enrollment of 88 is above the median of 53 across 27 interventional studies indexed under Dental Pulp Exposure.
Browse Dental Pulp Exposure studies →Aydin Adnan Menderes University is the lead sponsor of 236 studies on the registry; 54 are open to participants now.
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Exclusion Criteria:
A cotton pellet soaked in 0.1% Octenidine will be applied to the exposed pulp area
Other: pulp lavage Octenidine
A cotton pellet soaked in 2.5% NaOCl will be applied to the exposed pulp area
Other: pulp lavage NaOCl
Use of Octenidine as a pulp irrigation solution in pulp capping for mature permanent teeth
Use of NaOCl as a pulp irrigation solution in pulp capping for mature permanent teeth
Post operative pain
Use of the Visual Analog Scale (VAS) following the procedure
Time frame: 24 hours
Post operative pain
Use of the Visual Analog Scale (VAS) following the procedure
Time frame: 48 hours
Post operative pain
Use of the Visual Analog Scale (VAS) following the procedure
Time frame: 72 hours
Pulp vitality-ct
Evaluation through cold testing
Time frame: 6 months
Pulp vitality-ept
Evaluation through electric pulp testing
Time frame: 6 months
Pulp vitality-pr
Evaluation through periapical radiographic examinations
Time frame: 6 months
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.
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Aydin Adnan Menderes University