An interventional study of proprioceptive stimulation in Healthy Subjects, sponsored by Facultat de ciencies de la Salut Universitat Ramon Llull. Not yet recruiting at 1 site in Spain. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-24.
Sponsored by Facultat de ciencies de la Salut Universitat Ramon Llull · Not applicable, Interventional, and Treatment
Through motor muscle potentials, we will observe how a peripheral somatosensory mechanical stimulus on key limb musculature communicates signals via afferent sensory fibers that encode proprioceptive signals from muscle spindles (particularly type Ia fibers) to the somatosensory cortex at rest, confirming the integrative hypothesis of movement.
These results would support interventions aimed at addressing sensory deafferentation present in multiple health conditions related to movement disorders, where disuse or immobilization lead to changes in movement patterns and a decrease in neuronal activation in somatosensory cortex areas involved in constructing voluntary movement.
Objective: To evaluate whether a proprioceptive stimulus applied to the limb of healthy subjects activates the corticospinal pathway, compared to a condition without stimulation, through the analysis of motor evoked potentials (MEPs).
Methods: Experimental and crossover. Each participant will serve as their own control and will be assessed under both stimulation (experimental) and no-stimulation (control) conditions.The stimulus will consist of intermittent mechanical pressure on the skin located at the neuromuscular motor points (NMPs) of the upper limb (biceps muscle (B) and wrist extensors (WE)) and the lower limb (rectus femoris of the quadriceps (RFQ) and tibialis anterior (TA).Motor evoked potentials (MEPs) will be recorded from the B, WE, RFQ, and TA muscles using transcranial magnetic stimulation (TMS).The optimal stimulation point (hotspot-the area where TMS generates the highest MEP) will be identified individually for the B, WE, RFQ, and TA muscles.Participants will be recruited at the facilities of the Faculty of Physiotherapy and Nursing of Castilla-La Mancha University (UCLM), in collaboration with the Toledo Physiotherapy Research Group (GIFTO) and the Faculty of Health Sciences, Blanquerna - Ramon Llull University.
Facultat de ciencies de la Salut Universitat Ramon Llull is the lead sponsor of 5 studies on the registry; 5 are open to participants now.
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Inclusion Criteria:
Good health status with no history of neuromuscular injuries, surgical interventions, or trauma affecting the central or peripheral nervous system.
Not currently taking drugs or medications known to affect the central nervous system, and not pregnant at the time of testing.
No metallic or electronic implants and no history of epilepsy.
(Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research)
Participants will not receive the stimulus, and MEP activity will be recorded under the same motor cortex stimulation conditions.
Participants will receive proprioceptive stimulation through the output plunger, applied continuously for 15 seconds, with 20-second rest intervals, over a total duration of 5 minutes. MEP activity will then be recorded via motor cortex stimulation.
Device: proprioceptive stimulation
Participants will receive proprioceptive stimulation continuously during the application of TMS pulses while MEP activity is recorded.
Device: proprioceptive stimulation
Condition without proprioceptive stimulation: Participants will not receive the stimulus, and MEP activity will be recorded under the same motor cortex stimulation conditions. Condition with proprioceptive stimulation 1: Participants will receive proprioceptive stimulation through the output plunger, applied continuously for 15 seconds, with 20-second rest intervals, over a total duration of 5 minutes. MEP activity will then be recorded via motor cortex stimulation. Condition with proprioceptive stimulation 2: Participants will receive proprioceptive stimulation continuously during the application of TMS pulses while MEP activity is recorded.
Motor evoked potentials (MEPs)
transcranial magnetic stimulation (TMS)
Time frame: 45 minuts
Plan to share: No
No publications or documents are linked to this record.
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Facultat de ciencies de la Salut Universitat Ramon Llull