An observational study in Acute Respiratory Failure, sponsored by Brian Driver. Recruiting at 9 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-11.
Sponsored by Brian Driver · Observational
This study will compare the sensitivity and specificity of waveform capnography versus colorimetric carbon dioxide detection to identify tracheal placement of the endotracheal tube during intubation of critically ill adults.
This is the only study on the registry with Brian Driver as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Critically ill adult patients undergoing emergency intubation
Exclusion Criteria:
Adult patients who are undergoing emergency intubation in the ED and ICU
Diagnostic Test: Colorimetric carbon dioxide (CO2) detection · Diagnostic Test: Waveform capnography
All patients will undergo colorimetric carbon dioxide (CO2) detection. The reading will be assessed by a clinician at the bedside who will answer yes or no to the following question, asked after 7 breaths have been delivered following intubation: "Is the color change consistent with a tube located in the trachea?"
All patients will undergo waveform capnography. The reading will be assessed by a clinician at the bedside who will answer yes or no to the following question, asked after 7 breaths have been delivered following intubation: " Is the waveform consistent with a tube located in the trachea?"
Sensitivity of the test of exhaled carbon dioxide to detect a endotracheal tube positioned in the trachea.
The primary endpoint is the sensitivity of each test (against the reference standard) to accurately detect the tube location within the trachea. The sensitivity of each CO2 detection method describes the probability that the CO2 detection method is consistent with a tube location in the trachea for a patient who has an endotracheal tube located inside the trachea.
Time frame: From intubation until 7 breaths from the ventilator are delivered, approximately 1 minute
Specificity of the test of exhaled carbon dioxide to detect a endotracheal tube positioned outside of the trachea.
The secondary endpoint is the specificity of each test (against the reference standard) to accurately detect the tube location outside of the trachea. The specificity of each CO2 detection method describes the probability that the CO2 detection method is consistent with non-tracheal tube location for a patient who has an endotracheal tube located outside the trachea (e.g., esophageal intubation).
Time frame: From intubation until 7 breaths from the ventilator are delivered, approximately 1 minute
Plan to share: Yes — The authors will share the full de-identified dataset beginning 12 months after publication until 48 months after publication for researchers testing a hypothesis outlined in an institutional review board approved protocol. These data can be accessed by emailing the corresponding author. A signed data access agreement will be required.
Supporting information: Study protocol, Sap, Analytic code
No publications or documents are linked to this record.
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