An interventional study of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) and NIV (Non Invasive Ventilation) in Anesthesia Induction, sponsored by Clinique Pasteur. Completed at 5 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-15.
Sponsored by Clinique Pasteur · Not applicable, Interventional, and Prevention
Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during apnoea. Complications associated with induction and intubation in the operating room are more frequent in obese patients. Preoxygenation is a cornerstone in the management of patients at risk of desaturation during induction. The study aims to compare two oxygenation strategies , in obese patients. Oxygenation using a combination of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) compared with NIV alone in the operating room for induction of general anaesthesia with orotracheal intubation.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's enrollment of 124 is above the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Clinique Pasteur is the lead sponsor of 15 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Procedure: NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen)
Procedure: NIV (Non Invasive Ventilation)
Combination of two procedures Preoxygenation prior to intubation with NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen). During intubation, NIV is stopped and apneic oxygenation is maintained with HFNO
Single procedure Preoxygenation prior to intubation with NIV (Non Invasive Ventilation).
Oxygen reserve
The lowest level of end-tidal oxygen concentration (EtO2)
Time frame: 2 minutes after intubation
SpO2
Peripheral oxygen saturation
Time frame: during preoxygenation; before intubation; during intubation; after intubation; 2 minutes after intubation
Rate of EtCO2
End-tidal carbon dioxide
Time frame: 2 minutes after intubation
Patient tolerance
Numerical Rating Scale (NRS) \[minimum value 0, maximum value 10\] higher score mean a better outcome
Time frame: Day 2, at study end
Adverse events
moderate and severe complications
Time frame: Perioperative/Periprocedural
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Clinique Pasteur