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CompletedNCT06901362Updated Dec 23, 2025

Seroprevalence and Vaccination Rate of Hepatitis B Virus and Varicella-zoster Virus Among Medical Students Under Immunizing Program

An observational study in Healthy and Healthy Adult, sponsored by Thammasat University. Completed at 1 site in Thailand. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-23.

Sponsored by Thammasat University · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
401
Ages
18 Years and older
Sex
All
01

Study summary

This study is a cross-sectional study. The study aims to determine the levels of immunity against hepatitis B virus and varicella-zoster virus in medical students.

Read the detailed description

This study is a cross-sectional study aimed at determining the levels of immunity against the hepatitis B virus and varicella virus in medical students. Additionally, it aims to compare the rate of increase in immunity levels before and after receiving the hepatitis B and varicella-zoster vaccines in medical students. Medical students aged 18 years or older are included in the study.

02

Conditions studied

  • Healthy
  • Healthy Adult

Keywords

  • hepatitis B virus
  • varicella-zoster virus
  • vaccination
  • immunizing program
  • medical students
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In context

Hepatitis B

1,045 studies on the registry are indexed under Hepatitis B; 139 are open to participants now.

This study's enrollment of 401 is close to the median of 365 across 251 observational studies indexed under Hepatitis B.

Browse Hepatitis B studies →

Lead sponsor

Thammasat University is the lead sponsor of 85 studies on the registry; 16 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Medical students aged 18 years or older are included.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Medical students
  • Age 18 years or older

Exclusion criteria

Exclusion Criteria:

  • Known cases of virus infection
  • Known cases of varicella-zoster virus infection
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Hepatitis B tests

Hepatitis B is a virus that infects the liver. These are separate tests: HBsAg positive usually means a current infection (a recent vaccination can briefly cause it too); total anti-HBc (HBcAb) positive means an infection now or in the past; HBV DNA measures how much virus is in the blood.

Some studies accept a past infection if HBV DNA is undetectable, sometimes with antiviral medicine during the study. Check what this study allows.

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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
401 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Medical students

    Medical students aged 18 years or older

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What researchers measure

Primary outcomes

  1. The seroprevalence of hepatitis B virus

    The immunity level against the hepatitis B virus is assessed.

    Time frame: From enrollment to the end of treatment at 6 months

  2. The seroprevalence of varicella-zoster virus

    The immunity level against varicella-zoster virus is assessed.

    Time frame: From enrollment to the end of treatment at 6 months

Secondary outcomes

  1. The vaccination rate of hepatitis B virus

    The vaccination rate of hepatitis B virus is assessed.

    Time frame: From enrollment to the end of treatment at 6 months

  2. The vaccination rate of varicella-zoster virus

    The vaccination rate of varicella-zoster virus is assessed.

    Time frame: From enrollment to the end of treatment at 6 months

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Study locations

1 site
  • Narongkorn Saiphoklang
    Pathum Thani, Changwat Pathum Thani 12120, Thailand
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References and documents

Publications

  • Techasathit W, Ratanasuwan W, Sonjai A, Sangsiriwut K, Anekthananon T, Suwanagool S. Vaccination against hepatitis B virus: are Thai medical students sufficiently protected? J Med Assoc Thai. 2005 Mar;88(3):329-34. PubMed 15962639 ↗
  • Baer G, Bonhoeffer J, Schaad UB, Heininger U. Seroprevalence and immunization history of selected vaccine preventable diseases in medical students. Vaccine. 2005 Mar 14;23(16):2016-20. doi: 10.1016/j.vaccine.2004.03.073. PubMed 15734076 ↗
  • Balbi O, Baldi S, Rizza S, Pietroiusti A, Perrone S, Coppeta L. Seroprevalence survey for Varicella among healthcare workers and medical students in Italy. Hum Vaccin Immunother. 2021 Feb 1;17(2):372-376. doi: 10.1080/21645515.2020.1771989. Epub 2020 Jul 9. PubMed 32643520 ↗
  • Pourakbari B, Shahbaznezhad L, Parvaneh N, Nikkhah S, Mahmoudi S, Teymuri M, Alyari A, Mamishi S. Seroepidemiology of Varicella Zoster Virus among children, adolescents and medical students in a referral children medical center, Tehran, Iran. Iran J Microbiol. 2012 Sep;4(3):136-8. PubMed 23066488 ↗
  • Sheek-Hussein M, Hashmey R, Alsuwaidi AR, Al Maskari F, Amiri L, Souid AK. Seroprevalence of measles, mumps, rubella, varicella-zoster and hepatitis A-C in Emirati medical students. BMC Public Health. 2012 Dec 5;12:1047. doi: 10.1186/1471-2458-12-1047. PubMed 23217121 ↗
  • Cardenas-Perea ME, Gomez-Conde E, Santos-Lopez G, Perez-Contreras I, Diaz-Orea MA, Gandara-Ramirez JL, Cruz Y Lopez OR, Marquez-Dominguez L, Sosa-Jurado F. Hepatitis B surface antibodies in medical students from a public university in Puebla, Mexico. Hum Vaccin Immunother. 2016 Jul 2;12(7):1857-62. doi: 10.1080/21645515.2016.1151587. Epub 2016 May 12. PubMed 27171749 ↗
  • Sartorelli P, Occhialini F, Miceli R, Pietronigro A, Bianciardi L, Salini C, Messina G. The seroprevalence of the hepatitis B virus in Italian medical students after 3 decades since the introduction of universal vaccination. Int J Occup Med Environ Health. 2022 Feb 15;35(1):75-80. doi: 10.13075/ijomeh.1896.01835. Epub 2021 Aug 25. PubMed 34448470 ↗
  • Tesfa T, Hawulte B, Tolera A, Abate D. Hepatitis B virus infection and associated risk factors among medical students in eastern Ethiopia. PLoS One. 2021 Feb 19;16(2):e0247267. doi: 10.1371/journal.pone.0247267. eCollection 2021. PubMed 33606777 ↗
  • Rathi A, Kumar V, Majhi J, Jain S, Lal P, Singh S. Assessment of knowledge, attitude, and practices toward prevention of hepatitis B infection among medical students in a high-risk setting of a newly established medical institution. J Lab Physicians. 2018 Oct-Dec;10(4):374-379. doi: 10.4103/JLP.JLP_93_18. PubMed 30498306 ↗
  • Yoda T, Katsuyama H. Analysis of antibody-negative medical students after hepatitis B vaccination in Japan. Hum Vaccin Immunother. 2021 Mar 4;17(3):852-856. doi: 10.1080/21645515.2020.1788309. Epub 2020 Aug 5. PubMed 32755433 ↗
  • Bianchi FP, Tafuri S, Larocca AMV, Germinario CA, Stefanizzi P. Long -term persistence of antibodies against varicella in fully immunized healthcare workers: an Italian retrospective cohort study. BMC Infect Dis. 2021 May 25;21(1):475. doi: 10.1186/s12879-021-06180-x. PubMed 34034659 ↗
  • Phattraprayoon N, Kakheaw J, Soonklang K, Cheirsilpa K, Ungtrakul T, Auewarakul C, Mahanonda N. Duration of Hepatitis B Vaccine-Induced Protection among Medical Students and Healthcare Workers following Primary Vaccination in Infancy and Rate of Immunity Decline. Vaccines (Basel). 2022 Feb 10;10(2):267. doi: 10.3390/vaccines10020267. PubMed 35214725 ↗

Individual participant data

Plan to share: Yes — IPD and documents will be available for sharing immediately after publication for a period of 2 years.

Supporting information: Study protocol, Statistical analysis plan, Clinical study report

Time frame: IPD and documents will be available for sharing immediately after publication for a period of 2 years.

Access criteria: All researchers will be able to access the IPD and supporting information via the repository website without restriction.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 23, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06901362
Lead sponsor
Thammasat University
Collaborators
Thammasat University Hospital
Responsible party
Narongkorn Saiphoklang, MD (Associate Professor, Thammasat University) — Principal investigator
First posted
Mar 28, 2025
Start date
Apr 1, 2025
Primary completion
Aug 31, 2025
Completion
Nov 30, 2025
Last update
Dec 23, 2025

Study contacts

Narongkorn Saiphoklang, MD
principal investigator · Thammasat University Faculty of Medicine

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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