An interventional study of EXERCISE TRAINING WITH OR WITHOUT MEDICATION in Sedentary Lifestyle and Aerobic Exercise, sponsored by Chang Gung Memorial Hospital. Completed at 1 site in Taiwan. Open to male participants aged 18 Years to 28 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-27.
Sponsored by Chang Gung Memorial Hospital · Not applicable, Interventional, and Basic science
This study explores how exercise affects blood platelets and their role in clotting. Regular exercise can influence how efficiently clots form in the body. Intense exercise tends to increase platelet activity and the expression of certain molecules on their surface, while moderate exercise can decrease this activity. Since platelets are responsible for blood clotting, understanding how they function can be crucial.
Understanding Platelets:
Platelets are blood cells that help in clotting. The mitochondria within platelets help regulate their function. If these mitochondria don't work properly, it can lead to issues with clotting. By examining how exercise changes platelet mitochondria, the investigators can potentially identify important markers for health and disease progression.
Study Design:
This study compares two types of exercise routines: circuit training and stationary bicycle training.
Participants will be randomly assigned to one of the two groups:
Circuit Training Group: This involves moving through different exercise stations within a set time, targeting various body parts. It's tailored for those who might find regular exercise challenging, helping to reduce fatigue in any single area and improve overall fitness.
Bicycle Training Group: This involves exercising on a stationary bike. Both exercise groups will engage in high-intensity interval training for about 40 minutes, five times a week, over six weeks.
Assessment: Participants will undergo tests to measure endurance and physical function.
Blood Sampling: Blood will be drawn before and after the exercise tests, with 20 milliliters taken from the arm vein. Blood samples will also be collected at the start and end of a 6-week intervention, totaling 80 milliliters throughout the study. This helps the investigators analyze how platelets are affected by exercise.
This study is designed to help the investigators better understand how different types of exercise can benefit platelet function and overall health. Participanting in this research could contribute to the knowledge about how could exercise influence blood clotting and related health conditions. Participants' involvement will include exercise routines or maintaining your current lifestyle, along with simple blood tests. Participation is highly valuable and can help pave the way for new health insights and treatments.
Chang Gung Memorial Hospital is the lead sponsor of 1,064 studies on the registry; 235 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION
Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION
Participants in the exercise groups were trained five times a week for six weeks. The regimen began with a 5-min warm-up and ended with a 5-min cool-down, both at 40% of heart rate reserved (HRR). The circuit training participants were trained for three bouts of 10-min moderate-intensity exercise (60% of HRR) with 1-min rest intervals at a stationary ergometer, a rowing machine, and an elliptical trainer, respectively. The cycling training group was trained on an ergometer for three bouts of 10-min cycling on a stationary ergometer.
Platelet mitochondrial respiration
The mitochondrial OXPHOS and ET capacities in platelets were analyzed.
Time frame: baseline and 2 days upon the completion of the 6-week intervention
Cardiopulmonary fitness
Graded Exercise Test was performed on an ergometer.
Time frame: baseline and 2 days upon the completion of the 6-week intervention
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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Chang Gung Memorial Hospital