An interventional study of HEPA + VOC collecting filter purifier and fake air purifier in Rhinitis Allergic, sponsored by Yonsei University. Recruiting at 1 site in Korea, Republic of. Open to participants aged 19 Years to 60 Years. Per ClinicalTrials.gov, last updated 2025-03-24.
Sponsored by Yonsei University · Not applicable, Interventional, and Supportive care
This study targets adult patients between the ages of 19 and 60 who were diagnosed with allergic rhinitis caused by indoor inhalation antigens. Patients with moderate to severe and persistent allergic rhinitis who continue to require medication such as antihistamines and nasal spray steroids for allergic rhinitis are the subjects of this study.
Patients who participate in the study will install air purifiers for a certain period of time and observe the objective and subjective improvement of rhinitis symptoms. The study is conducted on two separate occasions for four weeks, and there is a two-week period between the two periods of no use of air purifiers. There are two types of air purifiers:
1)It is an air purifier with a HEPA filter and a VOC filter, and 2) a fake air purifier without air cleaning function.
Subjects are divided into Group A and Group B. Group A will receive a fake air purifier, and Group B will be assigned an air purifier with a HEPA + VOC collecting filter. After using the assigned air purifier for the first four weeks, you will have a period of not using it for two weeks, and then replace the air purifiers with each other and use it again for four weeks. When you first assign an air purifier, you will receive an air purifier with a certain filter It is randomly assigned without knowing whether both the researcher and the patient will receive a regular period.
During the study period, patients need to visit three times, including when registering for the study, and the study period is screened It will take about 5 months from the end of the air purifier operation
This study targets adult patients between the ages of 19 and 60 who were diagnosed with allergic rhinitis caused by indoor inhalation antigens. Patients with moderate to severe and persistent allergic rhinitis who continue to require medication such as antihistamines and nasal spray steroids for allergic rhinitis are the subjects of this study.
Patients who participate in the study will install air purifiers for a certain period of time and observe the objective and subjective improvement of rhinitis symptoms. The study is conducted on two separate occasions for four weeks, and there is a two-week period between the two periods of no use of air purifiers. There are two types of air purifiers:
1)It is an air purifier with a HEPA filter and a VOC filter, and 2) a fake air purifier without air cleaning function.
Subjects are divided into Group A and Group B. Group A will receive a fake air purifier, and Group B will be assigned an air purifier with a HEPA + VOC collecting filter. After using the assigned air purifier for the first four weeks, you will have a period of not using it for two weeks, and then replace the air purifiers with each other and use it again for four weeks. When you first assign an air purifier, you will receive an air purifier with a certain filter It is randomly assigned without knowing whether both the researcher and the patient will receive a regular period.
During the study period, patients need to visit three times, including when registering for the study, and the study period is screened It will take about 5 months from the end of the air purifier operation
A detailed chronological overview of the study is as follows
Screening and Baseline Visits (Visit 1) Before the process of the study begins, the study subjects are fully explained about the entire research process and checked whether they meet the selection and exclusion criteria. If the selection criteria are met, a written consent form will be written, basic demographic information (gender, age, medical history (including allergic disease-related and surgical history), and drug administration history (four weeks before registration). We will conduct a survey on subjective symptoms of allergic rhinitis, drug use scores, subjective score indicators, and quality of life evaluation indicators, and double-check the drugs currently being taken by the study subjects.
If you have previously used drugs for allergic rhinitis, you can maintain the medication without change and prescribe additional relief drugs if necessary.
Installation of air purifier and Study I after randomization Randomization is a method that is divided into groups A and B and is assigned based on a randomized list (random table) with statistician advice at a ratio of 1:1 respectively.
The first study (Study I) will run for four weeks. During this period, the air purifier will continue to operate, and no indoor ventilation will be performed for these four weeks to reduce other factors that may affect indoor air quality. After four weeks, the air purifier will be remotely controlled, and indoor air quality information will be continuously collected in the filter replacement.
The subject of the study should visit the hospital with symptoms and drug use log even at the end of the visit, and the change in symptoms and the use of relief drugs will be confirmed. At the end of the study, we will disclose which group the study subjects were assigned to.
178 studies on the registry are indexed under Rhinitis, Allergic, Perennial; 9 are open to participants now.
This study's planned enrollment of 44 is below the median of 135 across 157 interventional studies indexed under Rhinitis, Allergic, Perennial.
Browse Rhinitis, Allergic, Perennial studies →Yonsei University is the lead sponsor of 1,418 studies on the registry; 241 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Group A will receive a fake air purifier during study period 1, and during study 2, the HEPA+VOC filter air purifier will be operated.
Device: HEPA + VOC collecting filter purifier · Device: fake air purifier
Group A will receive the HEPA+VOC filter air purifier during study period 1, and during study 2, a fake air purifier will be operated.
Device: HEPA + VOC collecting filter purifier · Device: fake air purifier
Subjects operate HEPA + VOC collecting filter purifier
Subjects operate fake air purifiers
Change of indoor total volatile organic compound concentration
The indoor air collected through the air purifier is analyzed to evaluate the total indoor volatile organic compound concentration.
Time frame: up to 12 weeks
Change of indoor formaldehyde concentrations
Measure the indoor formaldehyde concentration through the air purifier
Time frame: up to 12 weeks
Change of indoor NO2 concentrations
Measure the indoor NO2 concentration through the air purifier
Time frame: up to 12 weeks
Change of indoor PM10 concentrations
Measure the indoor PM10 concentration through the air purifier
Time frame: up to 12 weeks
Change of indoor PM2.5 concentrations
Measure the indoor PM2.5 concentration through the air purifier
Time frame: up to 12 weeks
Change of indoor PM1.0 concentrations
Measure the indoor PM1.0 concentration through the air purifier
Time frame: up to 12 weeks
Change of Allergic rhinitis symptom score (Total natal symtom score)
TNSS has a total score of 12, and evaluate the degree of runny nose, sneezing, stuffy nose, and itchy nose. A score of 0 is no symptom, a score of 1 is mild (symptomatic/symptomatic but mild and easily tolerable), a score of 2 is moderate (symptomatic/symptomatic but tolerable), and a score of 3 is severe (symptomatic/symptomatic and difficult to bear and interfere with daily life or sleep). the higher the score, the more severe the rhinitis symptoms
Time frame: up to 12 weeks
Changes in the use of anti-allergic rhinitis medication (Rescue Medication Score)
Rescue Medication Score is evaluated from 0 to 2. A score of 0 means no additional medication, a score of 1 means additional use of oral or nasal antihistamines, and a score of 2 means additional use of nasal steroids, and a higher score means more rhinitis symptoms
Time frame: up to 12 weeks
A change in Quality of Life by Allergic Rhinitis
Evaluate using the quality of life questionnaire. The quality of life evaluation questionnaire is a questionnaire investigating the impact of allergic rhinitis on patients' lives for a week. The higher the score, with a total score of 60, the more severe the symptoms of rhinitis.
Time frame: up to 12 weeks
Change of odor score
valuate the subjective level of smell that a subject feels in the home. A score of 0 is odorless (relatively odorless and usually unable to detect anything with his or her sense of smell), a score of 1 is a sensed smell (the smell is unknown but capable of feeling the smell), a score of 2 is a normal smell (the smell is strong enough to know what it is), a score of 3 is a strong smell (the smell is strong enough to detect easily), a score of 4 is an extreme smell (a strong smell, for example, from a conventional toilet in summer), and a score of 5 is an unbearable smell (the strong smell that is difficult to endure and feels like stopping breathing). A total of five points means that the higher the score, the more severe the smell is.
Time frame: up to 12 weeks
Change in the time required for indoor pollutants to decrease from maximum concentration to baseline
Through the data collected by the air purifier, the time required for the indoor pollutant source to be reduced from the maximum concentration to the baseline is measured.
Time frame: up to 12 weeks
Plan to share: No
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