An observational study in Hip Arthroplasty Replacement, sponsored by Copenhagen University Hospital, Hvidovre. Recruiting at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-21.
Sponsored by Copenhagen University Hospital, Hvidovre · Observational
Clinical assessment of bleeding and calculation of perioperative blood loss do not provide an accurate estimate of blood volume. This makes rational fluid management difficult, which is of high importance for patient-related outcomes. The availability of carbon monoxide(CO)-rebreathing allows for simple, non-invasive and precise measurement of changes in blood volume.
The purpose of the study is to investigate and describe changes in blood volume and fluid distribution perioperative in patients undergoing total hip arthroplasty. Furthermore, to investigate the association between changes in blood volume and incidence of orthostatic insufficiency.
Patients scheduled for an elective total hip arthoplasty (THA) at Hvidovre University Hospital and undergo the proceduce under spinal anesthesia with propofol sedation.
Exclusion Criteria:
Change in total blood volume (TBV)
Measured in milliliter (mL)
Time frame: Preoperatively and 6 hours postoperatively
Change in total blood volume (TBV)
measured in mL
Time frame: Preoperatively and 24 hours postoperatively
Changes in total hemoglobin mass (tHgb)
Measured in gram (g)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in erythrocyte volume (EBV)
Measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in plasma volume (PV)
Measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in hematokrit (Ht)
Reported as percentage(%)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in hemoglobin (Hg) concentration
Measured in millimoles/liter(mmol/L)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in Total body water(TBW), intra-(ICF) and extracellular(ECF) fluid distribution
Full body water via bioelectrical impedance analysis. The individual components are reported in L and percent.
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Changes in C-Reactive Protein (CRP)
Measured in milligram/liter (mg/L)
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Incidence of orthostatic intolerance during mobilization
Symptoms of orthostatic intolerance: dizziness, nausea, vomiting, blurry vision or syncope during mobilization
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between total blood loss and incidence of orthostatic intolerance
Blood loss measured in mL. Symptoms of orthostatic intolerance: dizziness, nausea, vomiting, blurry vision or syncope during mobilization
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between changes in C-Reactive Protein and total blood loss
C-Reactive Protein measured in mg/L and total blood loss measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between peripheral perfusion index and total blood loss
Peripheral perfusion index measured in percent and total blood loss in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Association between total hemoglobin (SpHb) and total blood loss
SpHb measured as gram/deciliter and total blood loss measured in mL
Time frame: Preoperatively, 6 hours postoperatively and 24 hours postoperatively
Intraoperativ estimation of bleeding
Measured by weighting gauze (gram)
Time frame: Intraoperative at end of the surgical procedure
Intraoperative bleeding
Measured by visual estimation in surgical drains (mL)
Time frame: Intraoperative at end of the surgical procedure
Plan to share: No
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Copenhagen University Hospital, Hvidovre