An observational study in Degenerative Lumbar Diseases, Cage and Machine Learning, sponsored by Hao Liu. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2025-03-21.
Sponsored by Hao Liu · Observational
The study focuses on identifying risk factors for cage subsidence after posterior lumbar interbody fusion (PLIF) and developing an interpretable machine learning model to predict these risks. It analyzes patients from two large teaching hospitals, using clinical, radiographic, and surgical parameters, including paraspinal muscle indices and bone density markers. A web-based application was developed to facilitate real-time clinical risk assessments using the machine learning model, enhancing surgical planning and reducing subsidence risks.
Hao Liu is the lead sponsor of 4 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
This retrospective study included patients with degenerative lumbar diseases who underwent single-level PLIF at the First and Second Affiliated Hospitals of Soochow University (January 2018-October 2023).A total of 620 patients from the First Affiliated Hospital comprised the training set, while 100 patients from the Second Affiliated Hospital formed the external validation set. The study adhered to the Declaration of Helsinki and was approved by the institutional ethics committee.
Exclusion Criteria:
Group A (n = 390): Lost IH value \<2 mm.Cage subsidence was defined as a lost IH value ≥2 mm during the follow-up period
Procedure: MR4
Lost IH value ≥2 mm.Cage subsidence was defined as a lost IH value ≥2 mm during the follow-up period
Procedure: MR4
The study is a clinical retrospective study and does not involve any interventional measures.
Bone density imaging indicator: Vertebral Bone Quality (VBQ)
VBQ is calculated by dividing the mean T1 signal intensity (L1-L4) by the cerebrospinal fluid (CSF) signal at L3
Time frame: Preoperative measurement for PLIF (Posterior Lumbar Interbody Fusion)
Plan to share: Yes — Before January 1,2026;in the form of paper. The original data of the trial will be uploaded to Genome Sequence Archive (GSA) (ngdc.cncb.ac.cn)
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Hao Liu