An interventional study of Connective Tissue Graft and Ribose Cross-Linked Thick Collagen Membrane in Peri-implant Mucosa Thickness, Peri-implant Mucosa Width and Peri-Implant Tissues, sponsored by Ömer Alperen Kırmızıgül. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-12-09.
Sponsored by Ömer Alperen Kırmızıgül · Not applicable, Interventional, and Treatment
Background:This study aimed to compare the effect of ribose cross-linked thick collagen membrane (RCCM) with that of subepithelial connective tissue graft (CTG) in sites with soft tissue deficiency in the horizontal aspect around the implant.
Methods:Single implant sites were included in the study of 20 systemically healthy patients. All procedures were performed concurrently with implant placement; SCTG was administered in ten patients, and RCCM in the other ten. Before the operation, the PIMT and peri-implant mucosa width (PIMW) were measured. Visual analog scale (VAS) and Oral Health Impact profile-14 (OHIP-14) scores were recorded on post-operative days 1, 3, and 7. At 1 and 3 months measurements were repeated.
Results:In terms of PIMT, an average increase of 1.87 mm was recorded in the RCCM group and 1.99 mm in the SCTG group. The rate of increase in PIMT was statistically similar in both the groups (p>0.05). The OHIP-14 and VAS scores were similar between the groups on days 1, 3, and 7. There was a decrease at 3 months in both the groups.
Conclusion:Within the limits of this study, RCCM provided a similar increase in PIMT as SCTG. RCCM is a promising alternative to SCTG for increasing the PIMT.
Keywords: Collagen, Connective tissue, Dental implants, Oral mucosa
This is the only study on the registry with Ömer Alperen Kırmızıgül as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Connective Tissue Graft
Other: Connective Tissue Graft
Ribose Cross-Linked Thick Collagen Membrane
Other: Ribose Cross-Linked Thick Collagen Membrane
Implant treatment was performed in 20 patients with a single tooth deficiency and soft tissue deficiency in the horizontal direction in the edentulous site. All patients received bone-level titanium implants. Soft tissue augmentation was performed simultaneously with implant treatment. The group were divided into CTG , and 10 patients were randomly assigned to group.
Implant treatment was performed in 20 patients with a single tooth deficiency and soft tissue deficiency in the horizontal direction in the edentulous site. All patients received bone-level titanium implants. Soft tissue augmentation was performed simultaneously with implant treatment. The groups were divided into RCCM, and 10 patients were randomly assigned to group.
Peri-implant Mucosa Thickness
Changes in peri-implant mucosal thickness at baseline, month 1 and month 3
Time frame: From the beginning to the 3rd month
Plan to share: No
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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