An interventional study of Acute psychological stress task (Paced Auditory Serial Addition Task) in Psychological Stress, Cardiometabolic Conditions and Mental Health, sponsored by Montana State University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-17.
Sponsored by Montana State University · Not applicable, Interventional, and Basic science
Volunteers for the study are asked to participate in two laboratory sessions. In the first laboratory session, volunteers are asked to provide a blood sample which will be used to measure factors related to health. Participants also complete questionnaires related to demographic and health-related information and undergo evaluations of their body composition. In the second laboratory visit, participants are asked to have cardiovascular, neuroendocrine, and inflammatory activity measured during a brief period of rest and during a short challenging psychological task. Participants will also complete questionnaires. The study is designed to examine the associations between experiences such as trauma and resiliency with changes in bodily systems during a challenge and current health.
This cross-sectional study will examine the association between factors of resiliency and trauma with physiological (cardiovascular, neuroendocrine, inflammatory) responses to acute stress and current mental and physical health. Study volunteers will include individuals who identify as American Indian and currently live on and near the Blackfeet Reservation. Study volunteers will be asked to provide information that will be used to measure: correlates of cardiometabolic and mental health, acute psychological stress, arterial stiffness. Results of the study will help increase knowledge of cardiometabolic and mental health in the context of past and ongoing trauma and resiliency.
783 studies on the registry are indexed under Stress, Psychological; 128 are open to participants now.
This study's planned enrollment of 400 is above the median of 85 across 632 interventional studies indexed under Stress, Psychological.
Browse Stress, Psychological studies →Montana State University is the lead sponsor of 41 studies on the registry; 10 are open to participants now.
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Exclusion Criteria:
Volunteers are presented with an audio playing of single digit numbers between 1 and 9. They are instructed to add the number with the number previously presented and say the answer out loud. Volunteers are told their performance is being scored by research assistants. Volunteers are also instructed to look at themselves in a mirror while partaking in the task. Volunteers are informed they can discontinue at any time. Volunteers complete brief questionnaires before and after the task to asses their perceptions of stress, arousal, and anxiety.
Behavioral: Acute psychological stress task (Paced Auditory Serial Addition Task)
Volunteers will complete a 4-minute Paced Auditory Serial Addition Task which is a standardized laboratory challenge that is widely used to monitor cardiovascular, neuroendocrine, and inflammatory responses in the laboratory.
Changes in systolic blood pressure activity from baseline to task
The mean systolic blood pressure (mmHg) will be subtracted from the mean of the task period.
Time frame: 10 minute resting baseline mean will be subtracted from the 4 minute task period for each value
Changes in diastolic blood pressure activity from baseline to task
The mean diastolic blood pressure (mmHg) will be subtracted from the mean of the task period.
Time frame: 10 minute resting baseline mean will be subtracted from the 4 minute task period for each value
Changes in heart rate activity from baseline to task
The mean heart rate (bpm) will be subtracted from the mean of the task period.
Time frame: 10 minute resting baseline mean will be subtracted from the 4 minute task period for each value
Change in cortisol from baseline to task
Salivary samples will be taken to measure cortisol (nmol/L) the mean from the peak stress period will be subtracted from the baseline
Time frame: Baseline will be subtracted from the peak (15 minutes after task onset, 35 minute task onset)
Changes in IL-6 from baseline to task
IL-6 (pg/mL) measured at baseline will be subtracted from the IL-6 measured post task.
Time frame: Baseline will be subtracted from the level 30 minutes after task onset.
Pulse wave velocity
Pulse wave velocity in m/s will be assessed by dual impedance cardiography as a non-invasive indicator of arterial stiffness. This measure will be derived from the 5 minute baseline period.
Time frame: 5 minutes
Resting systolic blood pressure
Resting systolic blood pressure (mmHg)
Time frame: 10 minutes
Resting diastolic blood pressure
Resting diastolic blood pressure (mmHg)
Time frame: 10 minutes
Inflammatory and anti-inflammatory cytokines
Circulating levels of C-reactive protein, interleukin-6, tumor necrosis factor-a, monocyte chemoattractant protein-1, interleukin-1b, interleukin-10, and adiponectin will be assessed via a blood draw. A composite score will be created.
Time frame: 5 minutes
Hemoglobin A1c
Hemoglobin A1c (nmol/L) will be assessed via blood draw
Time frame: 5 minutes
Glucose
Glucose (nmol/L) will be assessed via blood draw
Time frame: 5 minutes
Insulin
Insulin (mL) will be assessed via blood draw
Time frame: 5 minutes
Cholesterol
Total cholesterol (mg) will be assessed via blood draw
Time frame: 5 minutes
Low-density lipoprotein
Low-density lipoprotein (mg/dL) will be assessed via blood draw
Time frame: 5 minutes
High-density lipoprotein
high-density lipoprotein (mg/dL) will be assessed via blood draw
Time frame: 5 minutes
Triglycerides
Triglycerides (mmol/L) will be assessed via blood draw
Time frame: 5 minutes
Waist circumference
Waist circumference
Time frame: 2 minutes
Hip circumference
Hip circumference
Time frame: 2 minutes
Depressive symptomology (Hospital Anxiety Depression Questionnaire depression subscale)
Hospital Anxiety Depression Questionnaire (depression subscale)
Time frame: 10 minutes
Depressive symptomology (PHQ-9)
PHQ-9
Time frame: 10 minutes
Anxiety symptomtology
Hospital Anxiety Depression Questionnaire (Anxiety subscale)
Time frame: 5 minutes
Alcohol use
Alcohol use will be assessed using the Alcohol Use Identification Test
Time frame: 10 minutes
Substance use
A cumulative score of substance use will be reported by indicating the number of recreational drugs "ever" tried
Time frame: 5 minutes
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