A Phase 1 interventional study of Placebo Comparator: Placebo and Low dose THC in Abuse Cannabis, Pain and Pharmacokinetics, sponsored by University of California, Los Angeles. Recruiting at 1 site in United States. Open to participants aged 21 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-04.
Sponsored by University of California, Los Angeles · Phase 1, Interventional, and Basic science
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
This outpatient study will assess the acute pharmacodynamic effects of smoked cannabis with \~50 mg and \~100 mg THC compared to placebo (\~0 mg THC) and whether a brief period of abstinence alters these effects. Metabolism (pharmacokinetics) of THC will be examined to associate behavioral and physiological effects to plasma concentrations of THC and metabolites.
517 studies on the registry are indexed under Marijuana Abuse; 114 are open to participants now.
This study's planned enrollment of 30 is below the median of 60 across 421 interventional studies indexed under Marijuana Abuse.
Browse Marijuana Abuse studies →University of California, Los Angeles is the lead sponsor of 1,142 studies on the registry; 192 are open to participants now.
Of its 91 completed or terminated interventional studies of FDA-regulated products, 66 (73%) have results posted.
Counted across the registry records on this site, refreshed daily.
Male or non-pregnant and non-lactating females aged 21-55 years
Exclusion Criteria:
0 mg THC
Drug: Placebo Comparator: Placebo
50 mg THC
Drug: Low dose THC
100 mg THC
Drug: High dose THC
Placebo
Also known as: Cannabis
Smoked low dose THC
Also known as: Cannabis
Smoked high dose THC
Also known as: Cannabis
Subject-rated drug effects of abuse liability
Subject ratings of "Good Drug Effect" as measured using a visual analog scale (1-100 mm)
Time frame: 3 hours
Analgesia as measured using the Cold Pressor Test
Pain threshold assessed using the Cold Pressor Test (percent baseline)
Time frame: 3 hours
Pharmacokinetics of THC and metabolites
Peak plasma levels of THC (ng/ml)
Time frame: 3 hours
Pharmacokinetics of THC and metabolites
Peak plasma levels of 11-OH-THC (ng/ml)
Time frame: 3 hours
Plan to share: No
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University of California, Los Angeles