An interventional study of Potato starch supplementation and Sodium butyrate supplementation in Healthy, sponsored by Wroclaw Medical University. Completed at 1 site in Poland. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-23.
Sponsored by Wroclaw Medical University · Not applicable, Interventional, and Basic science
Recent data feature short-chain fatty acids (SCFAs), products of gut microbial fermentation, as modulators of the blood pressure of the host. Such modulation may evoke (or arise from) changes in the autonomic reflexive mechanisms, but the link remains unexplored. Therefore, the study aims to explore potential relationship between the dietary intervention-induced changes in the SCFA plasma/fecal content and alterations in the sensitivity of the cardio-respiratory autonomic reflexes.
In this cross-over, placebo-controlled study, a group of healthy volunteers will undergo three distinct stages of a four-week dietary intervention, separated by at least two weeks of washout periods. During each stage, participants will receive one of the following interventions:
Wroclaw Medical University is the lead sponsor of 93 studies on the registry; 28 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dietary Supplement: Potato starch supplementation
Dietary Supplement: Sodium butyrate supplementation
Dietary Supplement: Accessible starch supplementation
Participants will receive potato starch supplement, undergoing gut microbial fermentation and acting as an endogenous source of the short-chain fatty acids, including butyrate. Effects of these compounds on the selected autonomic functions (i.e. cardio-respiratory control) will be further investigated.
Participants will receive sodium butyrate supplement, acting as an exogenous source of the short-chain fatty acid butyrate. Effects of such compound on the selected autonomic functions (i.e. cardio-respiratory control) will be further investigated.
Participants will receive the accessible (digestible) waxy maze starch as placebo.
Arterial baroreflex sensitivity
Arterial baroreflex sensitivity, measured with a neck chamber technique.
Time frame: From the beginning to the end of a supplementation period at 4 weeks.
Peripheral chemoreflex sensitivity
Peripheral chemoreflex sensitivity, measured with the transient hypoxia test.
Time frame: From the beginning to the end of a supplementation period at 4 weeks.
Plasma short-chain fatty acids
Plasma level of short-chain fatty acids, evaluated with high-performance liquid chromatography.
Time frame: From the beginning to the end of a supplementation period at 4 weeks.
Plan to share: No — This is a small trial which includes solely healthy volunteers. Therefore, data will not be shared at this instance.
No publications or documents are linked to this record.
This study is completed, as verified in Sep 2025. You cannot join it, but the record below documents what was studied.
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Wroclaw Medical University