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Active, not recruitingNCT06848816DUTRAPYLUpdated Feb 27, 2025

Duration of Antibiotic Therapy in Acute Kidney Graft Pyelonephritis (AGPN): Effect on the Risk of Recurrence

An observational study in Pyelonephritis Acute and Kidney Transplantation Recipients, sponsored by Central Hospital, Nancy, France. Active, not recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-27.

Primary conditionnone(registry's first term: Recurrence)No conditionIs this wrong?Recurrence describes something many studies share rather than a condition a study is about. The study names no condition we can place it under, so it is not compared with other studies by condition.

Sponsored by Central Hospital, Nancy, France · Observational

From the registry’s dates

  • Primary completion was expected by Apr 2025, 1 year 6 months ago, but the record still lists the study as active, not recruiting.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
500
Ages
18 Years and older
Sex
All
01

Study summary

The aim of this study is to evaluate the impact of the duration of antibiotic therapy on the risk of recurrence in kidney graft pyelonephritis. The secondary objectives are to identify the factors associated with the duration of antibiotic therapy in acute kidney graft pyelonephritis, identify the factors associated with recurrence of acute kidney graft pyelonephritis within 3 months, evaluate the impact of the duration of antibiotic therapy on antibiotic-related complications and assess the impact of the duration of antibiotic therapy on the progression of renal function after acute kidney graft pyelonephritis.

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Conditions studied

  • Pyelonephritis Acute
  • Kidney Transplantation Recipients

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Keywords

  • Acute graft pyelonephritis
  • duration treatment
  • antibiotic
  • recurrence
  • relapse
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In context

Lead sponsor

Central Hospital, Nancy, France is the lead sponsor of 798 studies on the registry; 186 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Every patient with AGPN during the study period

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult patients
  • Kidney transplant recipients with a functional graft.
  • Hospitalization with acute pyelonephritis (APN) defined by fever OR chills (noted in the clinical records) AND bacteriuria AND exclusion of another obvious cause of fever. (For rehospitalizations, also include cases where antibiotic therapy was initiated based on suspicion, even in the absence of documented infection.)

Exclusion criteria

Exclusion Criteria:

  • Age \< 18 years.
  • Vacationing patient or lost to follow-up with follow-up \< 3 months.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
500 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Relaspe AGPN

    Rehospitalization for acute kidney graft pyelonephritis (AGPN) within three months after completion of treatment

    Time frame: 3 month

Secondary outcomes

  1. Early AGPN relapse

    Rehospitalization for acute kidney graft pyelonephritis (AGPN) within one month after completion of treatment

    Time frame: 1 month

  2. ITU relapse

    Antibiotic treatment for urinary tract infection within 3 months after completion of treatment.

    Time frame: 3 month

  3. Identical microorganism relapsing AGPN

    New episode of AGPN with the same pathogen within 3 months after completion of treatment

    Time frame: 3 month

  4. Multidrug resistant emerging pathogens

    Infection with a multidrug-resistant bacteria within 3 months after completion of treatment

    Time frame: 3 month

  5. Clostridioides difficile colitis

    Occurrence of Clostridioides difficile colitis within 3 months after completion of treatment

    Time frame: 3 month

  6. Early kidney function evolution

    Evolution of renal function (creatininemia) 1 month after completion of treatment for APNAG.

    Time frame: 1 month

  7. 3 month kidney function evolution

    Evolution of renal function (creatininemia) 3 +/- 21 days after completion of treatment for AGPN

    Time frame: 3 month and 21 days

  8. Risk factors

    Clinical and biological Factors associated with AGPN recurrence independently of the duration of antibiotic therapy

    Time frame: 3 month

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Study locations

1 site
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 27, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06848816
Responsible party
CORBEL Alice (M.D., Central Hospital, Nancy, France) — Principal investigator
First posted
Feb 27, 2025
Start date
Jan 1, 2020
Primary completion
Apr 30, 2025 (estimated)
Completion
Dec 31, 2025 (estimated)
Last update
Feb 27, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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