An interventional study of Ketone ester and Placebo in Exercise and Metabolism, sponsored by University of Bath. Active, not recruiting at 1 site in United Kingdom. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-02-26.
Sponsored by University of Bath · Not applicable, Interventional, and Basic science
Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance.
The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.
University of Bath is the lead sponsor of 91 studies on the registry; 21 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Energy matched placebo containing medium-chain triglycerides and bitter taste
Dietary Supplement: Placebo
Beta-hydroxybutyrate monoester
Dietary Supplement: Ketone ester
0.29 g per kilogram body mass per hour of ketone monoester (R)-3-hydroxybutyrate (R)-3-hydroxybutyl
Medium chain triglycerides and bitter tastant (Bitrex)
Glucose concentrations
Blood glucose concentrations during the recovery period (240 minutes)
Time frame: 240 minutes
Non-oxidative fate of ingested sucrose
Non-oxidative fate of ingested glucose measured by appearance of 13C on breath CO2 from high 13C sucrose ingested during recovery
Time frame: 240 minutes
Exercise capacity
Time to exhaustion running at 70% of maximal aerobic capacity after the recovery period
Time frame: 240 minutes
Blood beta-hydroxybutyrate concentrations
Blood beta-hydroxybutyrate concentrations throughout the 240 minute recovery
Time frame: 240 minutes
Urinary urea
Urea in urine, determined by urea concentration multiplied by total urine output during the 240 minutes of recovery
Time frame: 240 minutes
Blood lactate concentrations
Blood lactate concentrations during 240 minutes of recovery
Time frame: 240 minutes
Plasma insulin concentrations
Plasma insulin concentrations during 240 minutes of recovery
Time frame: 240 minutes
Blood pH
Blood pH during 240 minutes of recovery
Time frame: 240 minutes
Blood bicarbonate
Blood bicarbonate concentrations during 240 minutes of recovery
Time frame: 240 minutes
Plan to share: Yes — Plan is to share individual deidentied data on a public repository such as Mendeleydata.
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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University of Bath