An interventional study of Clinicians and VenitlO in Mechanical Ventilation Complication and Respiratory Acidosis, sponsored by Laval University. Recruiting at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-09-04.
Sponsored by Laval University · Not applicable, Interventional, and Other
This is a randomized, open-label study comparing intial settings made by clinicians with settings recommandation made by the VentilO application immediately after intensive care unit admission.The study will allow direct comparison of the frequency of acidosis when patients are ventilated using the parameters of the VentilO application versus parameters chosen by the clinician. The variables determined by the clinician or VentilO will be respiratory rate, tidal volume and resulting minute ventilation.
Laval University is the lead sponsor of 371 studies on the registry; 68 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Clinicians include respiratory therapists, physcians, medical students
Other: Clinicians
VentilO, smartphone application (or web plateform)
Device: VenitlO
Clinicians will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit.
VentilO application (or web platerform) will determine respiratory parameters for mechanical ventilation upon arrival in the intensive care unit.
Respiratory acidosis
The frequency of respiratory acidosis on arterial gas after 20 minutes of mechanical ventilation (pH \< 7.35 and PaCO2 \> 45mmHg)
Time frame: 20 minutes after initiation of mechanical ventilation
Acid-base disorders on arrival in intensive care
The frequency and severity of acid-base disorders on arrival in intensive care (pH\<7.35 or pH \> 7.45)
Time frame: 5 minutes after initiation of mechanical ventilation
Number of participants with hemodynamic shock - hypotension
Requiring \>1L of volume repletion and/or use of amines at \>0.05 mcg/kg/min or norepinephrine equivalent
Time frame: Up to extubation
Number of participants with a barotrauma
Presence of pneumothorax
Time frame: Up to extubation
Mortality
Intensive care unit mortality
Time frame: Up to intensive care unit discharge
Intensive care unit lenght of stay
Intensive care unit lenght of stay
Time frame: Up to 28 days - intensive care unit length of stay - intensive care admission to intensive care discharge
Number of participants with an acute kidney injury
Acute kidney injury define by \> 27 mmol for 48 hours or 1.5 x basline value (pre surgery)
Time frame: Up to 28 days - intensive care unit length of stay - intensive care admission to intensive care discharge
Plan to share: No
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Acidosis, Respiratory
Laval University