CompletedNCT06826508Updated Feb 14, 2025

Modes of Delivery Impact Maternal Oxidative Stress Biomarkers and Dynamic Thiol Disulphide Homeostasis

An observational study in Vaginal Delivery, Cesarian Section and Oxidative Stress, sponsored by Mardin Artuklu University. Completed at 1 site in Turkey. Open to female participants aged 20 Years to 36 Years. Per ClinicalTrials.gov, last updated 2025-02-14.

Sponsored by Mardin Artuklu University · Observational

Study type: Observational
Model: Case-control
Time perspective: Prospective
Enrollment: 58
Ages: 20 Years to 36 Years
Sex: Female

Study summary

Modes of delivery impact maternal oxidative stress biomarkers and dynamic thiol disulphide homeostasis

Conditions studied

Vaginal Delivery
Cesarian Section
Oxidative Stress

In context

Lead sponsor

Mardin Artuklu University is the lead sponsor of 26 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 20 Years to 36 Years
Sexes eligible: Female
Accepts healthy volunteers: No
Sampling method: Probability sample

Study population

Pregnant women

Inclusion criteria

For VD group:

Women with spontaneous uncomplicated vaginal delivery
Women who were in the 38th week and vertex presentation and whose contractions had started naturally.

For CS group:

Women in their 38th week of pregnancy who delivered by elective CS without uterine contractions

Exclusion criteria

Exclusion Criteria:

Participants who were smokers
Participants who had a non-optimal pre-pregnancy body mass index
Systemic diseases such as diabetes mellitus and gestational hypertension.

Study design

Observational model: Case-control
Time perspective: Prospective
Enrollment: 58 participants (actual)
Patient registry: No

Groups and cohorts

vaginal delivery
35 women who had spontaneous vaginal deliveries
cesarean section
23 women who had elective cesarean sections without labor

What researchers measure

Primary outcomes

Oxidative stress markers
Total antioxidation state (μmol Trolox equivalent/ L),
Time frame: From January 2021 to August 2021
Oxidative stress markers
Total oxidation status(μmol H2O2 equivalent/L)
Time frame: From January 2021 to August 2021
Oxidative stress markers
Oxidative stress index (arbitrary unit)
Time frame: From January 2021 to August 2021
Oxidative stress markers
Disulfide (-S-S-) (µmol / L) / alb (g / l)
Time frame: From January 2021 to August 2021
Oxidative stress markers
Total thiol (µmol / L)
Time frame: From January 2021 to August 2021
Oxidative stress markers
Native thiol (µmol / L) / alb (g / l)
Time frame: From January 2021 to August 2021
Oxidative stress markers
Ischemia modified albumin (U/L)
Time frame: From January 2021 to August 2021
Oxidative stress markers
Paroxanase (U/L)
Time frame: From January 2021 to August 2021
Oxidative stress markers
Arylesterase (Ku/l)
Time frame: From January 2021 to August 2021

Study locations

1 site

Alanya Training and Research Hospital Gynecology and Obstetrics Department
Antalya, Turkey

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Feb 14, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT06826508
Lead sponsor: Mardin Artuklu University
Collaborators: Alanya Alaaddin Keykubat University
Responsible party: Hasan Basri Savas (Associate Professor, Mardin Artuklu University) — Principal investigator
First posted: Feb 14, 2025
Start date: Jan 3, 2021
Primary completion: Aug 30, 2021
Completion: Dec 1, 2021
Last update: Feb 14, 2025

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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