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CompletedNCT06824389Updated Jan 8, 2026

Evaluate the Performance of Large Language Models in Ophthalmologic Patient Consultation

An interventional study of Consultation Model of large language model in Ophthalmology Clinics in Non-emergency Ocular Diseases, sponsored by Zhongshan Ophthalmic Center, Sun Yat-sen University. Completed at 1 site in China. Per ClinicalTrials.gov, last updated 2026-01-08.

Sponsored by Zhongshan Ophthalmic Center, Sun Yat-sen University · Not applicable, Interventional, and Screening

Phase
Not applicable
Study type
Interventional
Enrollment
172
Allocation
Randomized
Sex
All
01

Study summary

The intelligent image models lack an understanding of diagnostic and treatment logic, and have not considered textual information such as symptoms and signs. Large language models like ChatGPT, can learn medical knowledge, understand, and generate human natural language, offering new technologies for medical knowledge-based intelligent question answering and the creation of smart medical documents. Therefore, our team plan to verify large language models' feasibility and effectiveness in ophthalmology clinics for medical history collection and examination recommendations during consultations, comparing its performance with traditional methods.

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Conditions studied

  • Non-emergency Ocular Diseases
03

In context

Lead sponsor

Zhongshan Ophthalmic Center, Sun Yat-sen University is the lead sponsor of 159 studies on the registry; 77 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • No age or gender restrictions for patients.
  • Non-emergency ocular diseases including corneal diseases, lens disorders, and vitreoretinal diseases.
  • Voluntary participation with signed informed consent.

Exclusion criteria

Exclusion Criteria:

  • Top 10 Ocular Emergencies: globe perforation, ocular chemical injury, corneal ulcer perforation, Pseudomonas aeruginosa keratitis, acute angle-closure glaucoma, acute panophthalmitis, central retinal artery occlusion, acute optic neuritis, endophthalmitis, and orbital cellulitis.
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Study design

Phase
Not applicable
Primary purpose
Screening
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
172 participants (actual)

Study arms

  • Experimental
    Large language models in consultation

    After the patient signs the informed consent form, the large language model completes the medical history collection and recommends examinations.

    Other: Consultation Model of large language model in Ophthalmology Clinics

  • No intervention
    Traditional consultation

    After the patient signs the informed consent form, doctor completes the medical history collection and recommends examinations.

Interventions

  • OtherConsultation Model of large language model in Ophthalmology Clinics

    Large language model completes the medical history collection and recommends examinations.

06

What researchers measure

Primary outcomes

  1. Medical History Collection Scoring

    The medical history collection is performed using the standard outpatient medical record form. The scoring criteria are developed collaboratively by clinical doctors from multiple specialties and researchers. Scoring is independently conducted in a blinded manner by higher-level specialists.

    Time frame: through study completion, up to 1 week.

Secondary outcomes

  1. Accuracy of Recommended Tests

    The gold standard for both the experimental and control groups consists of test items independently selected by senior specialists, who are not involved in the study.

    Time frame: through study completion, up to 1 week.

  2. Duration of Medical History Collection

    The experimental group uses the developed system to record the consultation and medical record writing completion times, while the control group records the consultation time through audio recording and the medical record writing completion time through the developed system.

    Time frame: through study completion, up to 1 week.

  3. Patient satisfaction

    Collected through a questionnaire.

    Time frame: through study completion, up to 1 week.

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Study locations

1 site
  • Zhongshan Ophthalmic Center, Sun Yat-sen University
    Guangzhou, Guangdong, China
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06824389
Lead sponsor
Zhongshan Ophthalmic Center, Sun Yat-sen University
Responsible party
Sponsor
First posted
Feb 13, 2025
Start date
May 10, 2025
Primary completion
Jun 10, 2025
Completion
Jun 17, 2025
Last update
Jan 8, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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